1H-Indole-2-carboxylic acid, 4,6-dichloro-3-[(1E)-3-(1,1-dimethylethoxy)-2-(4-methoxyphenyl)-3-oxo- 1-propenyl]-1-[(4-methylphenyl)sulfonyl]-, ethyl ester

Base Information

Chemical Name:1H-Indole-2-carboxylic acid, 4,6-dichloro-3-[(1E)-3-(1,1-dimethylethoxy)-2-(4-methoxyphenyl)-3-oxo- 1-propenyl]-1-[(4-methylphenyl)sulfonyl]-, ethyl ester
CAS No.:179106-71-9
Molecular Formula:C32H31Cl2NO7S
Molecular Weight:644.573
Hs Code.:

1H-Indole-2-carboxylic acid,
4,6-dichloro-3-[(1E)-3-(1,1-dimethylethoxy)-2-(4-methoxyphenyl)-3-oxo-
1-propenyl]-1-[(4-methylphenyl)sulfonyl]-, ethyl ester

Synonyms:

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Chemical Property of 1H-Indole-2-carboxylic acid, 4,6-dichloro-3-[(1E)-3-(1,1-dimethylethoxy)-2-(4-methoxyphenyl)-3-oxo- 1-propenyl]-1-[(4-methylphenyl)sulfonyl]-, ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
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Useful:

Technology Process of 1H-Indole-2-carboxylic acid, 4,6-dichloro-3-[(1E)-3-(1,1-dimethylethoxy)-2-(4-methoxyphenyl)-3-oxo- 1-propenyl]-1-[(4-methylphenyl)sulfonyl]-, ethyl ester

There total 8 articles about 1H-Indole-2-carboxylic acid, 4,6-dichloro-3-[(1E)-3-(1,1-dimethylethoxy)-2-(4-methoxyphenyl)-3-oxo- 1-propenyl]-1-[(4-methylphenyl)sulfonyl]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 179106-70-8
(Z)-3-(2-bromo-2-(tert-butoxycarbonyl)vinyl)-4,6-dichloro-1-(toluene-4-sulfonyl)-1H-indole-2-carboxylic acid ethyl ester

: 5720-07-0
4-methoxyphenylboronic acid

: 179106-71-9
(Z)-2-(4-Methoxyphenyl)-3-(1-p-toluenesulfonyl-2-carboethoxy-4,6-dichloroindol-3-yl)propenoic acid, t-butyl ester

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trifuran-2-yl-phosphane; potassium carbonate; In tetrahydrofuran; at 55 - 60 ℃; for 216h;
DOI:10.1021/jm0491849

Reference yield:

: 179106-93-5
bromo(diethoxyphosphoryl)acetic acid tert-butyl ester

: 179106-71-9
(Z)-2-(4-Methoxyphenyl)-3-(1-p-toluenesulfonyl-2-carboethoxy-4,6-dichloroindol-3-yl)propenoic acid, t-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: LiHMDS / tetrahydrofuran / 0.17 h / -78 °C

1.2: 53 percent / tetrahydrofuran / 2 h / -78 - 20 °C

2.1: 427 mg / tri-2-furylphosphine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾; K₂CO₃ / tetrahydrofuran / 216 h / 55 - 60 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trifuran-2-yl-phosphane; potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; 1.2: Horner-Emmons reaction / 2.1: Suzuki-Miyaura reaction;
DOI:10.1021/jm0491849

Reference yield:

: 179106-94-6
dibromo(diethoxyphosphoryl)acetic acid tert-butyl ester

: 179106-71-9
(Z)-2-(4-Methoxyphenyl)-3-(1-p-toluenesulfonyl-2-carboethoxy-4,6-dichloroindol-3-yl)propenoic acid, t-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 91 percent / aq. SnCl₂ / 2-methyl-propan-2-ol / 0.25 h / cooling

2.1: LiHMDS / tetrahydrofuran / 0.17 h / -78 °C

2.2: 53 percent / tetrahydrofuran / 2 h / -78 - 20 °C

3.1: 427 mg / tri-2-furylphosphine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾; K₂CO₃ / tetrahydrofuran / 216 h / 55 - 60 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trifuran-2-yl-phosphane; potassium carbonate; tin(ll) chloride; lithium hexamethyldisilazane; In tetrahydrofuran; tert-butyl alcohol; 2.2: Horner-Emmons reaction / 3.1: Suzuki-Miyaura reaction;
DOI:10.1021/jm0491849