Technology Process of Propanal,
3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-[(4-methoxyphenyl)methoxy]-,
(2S)-
There total 3 articles about Propanal,
3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-[(4-methoxyphenyl)methoxy]-,
(2S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 85 percent / DIBAL-H / petroleum ether / 4 h / 0 - 20 °C
2: 90 percent / (COCl)2; DMSO; iPr2NEt / -78 °C
With
oxalyl dichloride; diisobutylaluminium hydride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine;
In
Petroleum ether;
2: Swern oxidation;
DOI:10.1016/j.tetlet.2007.04.148
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 77 percent / TfOH / diethyl ether / 0.5 h / 20 °C
2: 85 percent / DIBAL-H / petroleum ether / 4 h / 0 - 20 °C
3: 90 percent / (COCl)2; DMSO; iPr2NEt / -78 °C
With
oxalyl dichloride; trifluorormethanesulfonic acid; diisobutylaluminium hydride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine;
In
diethyl ether; Petroleum ether;
3: Swern oxidation;
DOI:10.1016/j.tetlet.2007.04.148
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: (R,R)-salen-Co(III)-OAc; H2O / diethyl ether / 18 h / 20 °C
1.2: pyridine / CH2Cl2 / 4 h / 0 - 20 °C
2.1: 77 percent / TfOH / diethyl ether / 0.5 h / 20 °C
3.1: 85 percent / DIBAL-H / petroleum ether / 4 h / 0 - 20 °C
4.1: 90 percent / (COCl)2; DMSO; iPr2NEt / -78 °C
With
oxalyl dichloride; (S,S)-(salen)cobalt(III)(OAc); trifluorormethanesulfonic acid; water; diisobutylaluminium hydride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine;
In
diethyl ether; Petroleum ether;
1.1: Jacobsen hydrolytic kinetic resolution / 4.1: Swern oxidation;
DOI:10.1016/j.tetlet.2007.04.148
