4-(4-Tert-butoxycarbonylaminobutyrylamino)-1-methyl-1h-imidazole-2-carboxylic acid

Base Information

Chemical Name:4-(4-Tert-butoxycarbonylaminobutyrylamino)-1-methyl-1h-imidazole-2-carboxylic acid
CAS No.:180258-48-4
Molecular Formula:C14H22N4O5
Molecular Weight:326.34800
Hs Code.:
DSSTox Substance ID:DTXSID401112929
Nikkaji Number:J757.305G
Mol file:180258-48-4.mol

Synonyms:180258-48-4;4-(4-tert-butoxycarbonylaminobutyrylamino)-1-methyl-1h-imidazole-2-carboxylic acid;1-methyl-4-[4-[(2-methylpropan-2-yl)oxycarbonylamino]butanoylamino]imidazole-2-carboxylic Acid;4-(4-tert-Butoxycarbonylaminobutyrylamino) -1-methyl-1H-imidazole-2-carboxylic acid;DTXSID401112929;4-(4-((tert-Butoxycarbonyl)amino)butanamido)-1-methyl-1H-imidazole-2-carboxylic acid;4-(4-((tert-Butoxycarbonyl)amino)butanamido)-1-methyl-1H-imidazole-2-carboxylicacid;4-(4-(tert-butoxycarbonylamino)butanamido)-1-methyl-1H-imidazole-2-carboxylic acid;1-Methyl-4-[[4-[[(tert-butyloxy)carbonyl]amino]butyryl]amino]-1H-imidazole-2-carboxylic acid;4-[[4-[[(1,1-Dimethylethoxy)carbonyl]amino]-1-oxobutyl]amino]-1-methyl-1H-imidazole-2-carboxylic acid

Suppliers and Price of 4-(4-Tert-butoxycarbonylaminobutyrylamino)-1-methyl-1h-imidazole-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Oakwood
4-(4-tert-Butoxycarbonylaminobutyrylamino)-1-methyl-1H-imidazole-2-carboxylicacid
1g
$ 145.00

Oakwood
4-(4-tert-Butoxycarbonylaminobutyrylamino)-1-methyl-1H-imidazole-2-carboxylicacid
250mg
$ 72.00

Crysdot
4-(4-((tert-Butoxycarbonyl)amino)butanamido)-1-methyl-1H-imidazole-2-carboxylicacid 97%
10g
$ 468.00

AHH
4-(4-tert-Butoxycarbonylaminobutyrylamino)-1-methyl-1H-imidazole-2-carboxylicacid 98%
10g
$ 240.00

Total 5 raw suppliers

Chemical Property of 4-(4-Tert-butoxycarbonylaminobutyrylamino)-1-methyl-1h-imidazole-2-carboxylic acid

Chemical Property:

PSA：122.55000
LogP:1.82560
XLogP3:0.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:8
Exact Mass:326.15901982
Heavy Atom Count:23
Complexity:449

Purity/Quality:

98%min ^*data from raw suppliers

4-(4-tert-Butoxycarbonylaminobutyrylamino)-1-methyl-1H-imidazole-2-carboxylicacid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NCCCC(=O)NC1=CN(C(=N1)C(=O)O)C

Technology Process of 4-(4-Tert-butoxycarbonylaminobutyrylamino)-1-methyl-1h-imidazole-2-carboxylic acid

There total 6 articles about 4-(4-Tert-butoxycarbonylaminobutyrylamino)-1-methyl-1h-imidazole-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 195387-60-1
4-(4-tert-Butoxycarbonylamino-butyrylamino)-1-methyl-1H-imidazole-2-carboxylic acid ethyl ester

: 180258-48-4
4-(4-tert-Butoxycarbonylamino-butyrylamino)-1-methyl-1H-imidazole-2-carboxylic acid

Guidance literature:: With sodium hydroxide; In methanol; at 60 ℃; for 6h; Yield given;
DOI:10.1021/ja960720z

Reference yield:

: 30148-21-1
ethyl 1-methyl-1H-imidazole-2-carboxylate

: 180258-48-4
4-(4-tert-Butoxycarbonylamino-butyrylamino)-1-methyl-1H-imidazole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 22 percent / HNO₃, H₂SO₄ / 0.83 h / Heating

2: H₂ / 10percent Pd/C / ethanol; ethyl acetate / 48 h / 836 Torr

3: diisopropylethylamine / dimethylformamide / 8 h / 60 °C

4: aq. NaOH / methanol / 6 h / 60 °C

With sodium hydroxide; sulfuric acid; hydrogen; nitric acid; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ja960720z

Reference yield:

: 109012-23-9
ethyl 1-methyl-4-nitroimidazole-2-carboxylate

: 180258-48-4
4-(4-tert-Butoxycarbonylamino-butyrylamino)-1-methyl-1H-imidazole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 10percent Pd/C / ethanol; ethyl acetate / 48 h / 836 Torr

2: diisopropylethylamine / dimethylformamide / 8 h / 60 °C

3: aq. NaOH / methanol / 6 h / 60 °C

With sodium hydroxide; hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ja960720z