6,7-Dimethoxy-4-methylisoquinoline

Base Information

Chemical Name:6,7-Dimethoxy-4-methylisoquinoline
CAS No.:18029-55-5
Molecular Formula:C12H13NO2
Molecular Weight:203.23700
Hs Code.:2933499090
DSSTox Substance ID:DTXSID10553577
Wikidata:Q82434194
Mol file:18029-55-5.mol

Synonyms:6,7-Dimethoxy-4-methylisoquinoline;18029-55-5;Isoquinoline, 6,7-dimethoxy-4-methyl- (8CI,9CI);DTXSID10553577;4-methyl-6,7-dimethoxyisoquinoline

Suppliers and Price of 6,7-Dimethoxy-4-methylisoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 6,7-Dimethoxy-4-methylisoquinoline

Chemical Property:

PSA：31.35000
LogP:2.56040
XLogP3:2.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:203.094628657
Heavy Atom Count:15
Complexity:210

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CN=CC2=CC(=C(C=C12)OC)OC

Technology Process of 6,7-Dimethoxy-4-methylisoquinoline

There total 6 articles about 6,7-Dimethoxy-4-methylisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 51698-53-4
2‐(3,4‐dimethoxyphenyl)propionitrile

: 18029-55-5
4-Methyl-6,7-dimethoxy-isochinolin

Guidance literature:: Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 90 °C / Inert atmosphere

2: 2 h / 0 - 190 °C

3: phosphorus pentachloride / toluene / 1 h / 120 °C

4: oxygen / ethanol

With lithium aluminium tetrahydride; phosphorus pentachloride; oxygen; In tetrahydrofuran; ethanol; toluene; 3: |Bischler-Napieralski Reaction;
DOI:10.1002/anie.201805060

Reference yield:

: 93-17-4
3,4-dimethoxyphenylacetonitrile

: 18029-55-5
4-Methyl-6,7-dimethoxy-isochinolin

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 1 h / -78 °C / Inert atmosphere

1.2: 1.5 h / -78 - 20 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 90 °C / Inert atmosphere

3.1: 2 h / 0 - 190 °C

4.1: phosphorus pentachloride / toluene / 1 h / 120 °C

5.1: oxygen / ethanol

With lithium aluminium tetrahydride; phosphorus pentachloride; oxygen; lithium diisopropyl amide; In tetrahydrofuran; ethanol; n-heptane; ethylbenzene; toluene; 4.1: |Bischler-Napieralski Reaction;
DOI:10.1002/anie.201805060

Reference yield:

: 55174-61-3
2-(3,4-dimethoxyphenyl)propan-1-amine

: 18029-55-5
4-Methyl-6,7-dimethoxy-isochinolin

Guidance literature:: Multi-step reaction with 3 steps

1: 2 h / 0 - 190 °C

2: phosphorus pentachloride / toluene / 1 h / 120 °C

3: oxygen / ethanol

With phosphorus pentachloride; oxygen; In ethanol; toluene; 2: |Bischler-Napieralski Reaction;
DOI:10.1002/anie.201805060