Technology Process of Isoquinoline, 6,7-dimethoxy-4-methyl- (8CI,9CI)
There total 6 articles about Isoquinoline, 6,7-dimethoxy-4-methyl- (8CI,9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 90 °C / Inert atmosphere
2: 2 h / 0 - 190 °C
3: phosphorus pentachloride / toluene / 1 h / 120 °C
4: oxygen / ethanol
With
lithium aluminium tetrahydride; phosphorus pentachloride; oxygen;
In
tetrahydrofuran; ethanol; toluene;
3: |Bischler-Napieralski Reaction;
DOI:10.1002/anie.201805060
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 1 h / -78 °C / Inert atmosphere
1.2: 1.5 h / -78 - 20 °C / Inert atmosphere
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 90 °C / Inert atmosphere
3.1: 2 h / 0 - 190 °C
4.1: phosphorus pentachloride / toluene / 1 h / 120 °C
5.1: oxygen / ethanol
With
lithium aluminium tetrahydride; phosphorus pentachloride; oxygen; lithium diisopropyl amide;
In
tetrahydrofuran; ethanol; n-heptane; ethylbenzene; toluene;
4.1: |Bischler-Napieralski Reaction;
DOI:10.1002/anie.201805060
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 2 h / 0 - 190 °C
2: phosphorus pentachloride / toluene / 1 h / 120 °C
3: oxygen / ethanol
With
phosphorus pentachloride; oxygen;
In
ethanol; toluene;
2: |Bischler-Napieralski Reaction;
DOI:10.1002/anie.201805060