2(1H)-Isoquinolinecarboxylic acid, 1-[(4-amino-3-iodophenyl)methyl]-3,4-dihydro-6,7-bis(phenylmethoxy)-, 1,1-dimethylethyl ester

Base Information

Chemical Name:2(1H)-Isoquinolinecarboxylic acid, 1-[(4-amino-3-iodophenyl)methyl]-3,4-dihydro-6,7-bis(phenylmethoxy)-, 1,1-dimethylethyl ester
CAS No.:180623-56-7
Molecular Formula:C35H37IN2O4
Molecular Weight:676.594
Hs Code.:

Synonyms:

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Chemical Property of 2(1H)-Isoquinolinecarboxylic acid, 1-[(4-amino-3-iodophenyl)methyl]-3,4-dihydro-6,7-bis(phenylmethoxy)-, 1,1-dimethylethyl ester

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Technology Process of 2(1H)-Isoquinolinecarboxylic acid, 1-[(4-amino-3-iodophenyl)methyl]-3,4-dihydro-6,7-bis(phenylmethoxy)-, 1,1-dimethylethyl ester

There total 8 articles about 2(1H)-Isoquinolinecarboxylic acid, 1-[(4-amino-3-iodophenyl)methyl]-3,4-dihydro-6,7-bis(phenylmethoxy)-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 180623-54-5
1-(4-Amino-benzyl)-6,7-bis-benzyloxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

: 180623-56-7
1-(4-Amino-3-iodobenzyl)-6,7-dibenzyloxy-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With N,N,N-trimethylbenzenemethanaminium dichloroiodate; calcium carbonate; In methanol; dichloromethane;
DOI:10.1021/jm960208o

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 180623-56-7
1-(4-Amino-3-iodobenzyl)-6,7-dibenzyloxy-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / 1N aq. NaOH / tetrahydrofuran / Ambient temperature

2: 71 percent / H₂ / Raney Ni / 3 h / 20 °C / 2585.7 Torr

3: 81 percent / benzyltrimethylammonium dichloroiodate, CaCO₃ / methanol; CH₂Cl₂

With sodium hydroxide; hydrogen; N,N,N-trimethylbenzenemethanaminium dichloroiodate; calcium carbonate; nickel; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm960208o

Reference yield:

: 104-03-0
4-nitrobenzeneacetic acid

: 180623-56-7
1-(4-Amino-3-iodobenzyl)-6,7-dibenzyloxy-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 6 steps

1: toluene / 72 h / Heating

2: POCl₃ / acetonitrile / Heating

3: NaBH₄ / methanol / Ambient temperature

4: 86 percent / 1N aq. NaOH / tetrahydrofuran / Ambient temperature

5: 71 percent / H₂ / Raney Ni / 3 h / 20 °C / 2585.7 Torr

6: 81 percent / benzyltrimethylammonium dichloroiodate, CaCO₃ / methanol; CH₂Cl₂

With sodium hydroxide; sodium tetrahydroborate; hydrogen; N,N,N-trimethylbenzenemethanaminium dichloroiodate; calcium carbonate; trichlorophosphate; nickel; In tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile;
DOI:10.1021/jm960208o