1-(4-Benzoylamino-3-iodobenzyl)-6,7-dibenzyloxy-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:1-(4-Benzoylamino-3-iodobenzyl)-6,7-dibenzyloxy-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinoline
CAS No.:180623-79-4
Molecular Formula:C₄₂H₄₁IN₂O₅
Molecular Weight:780.702
Hs Code.:

Synonyms:1-(4-Benzoylamino-3-iodobenzyl)-6,7-dibenzyloxy-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of 1-(4-Benzoylamino-3-iodobenzyl)-6,7-dibenzyloxy-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinoline

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Technology Process of 1-(4-Benzoylamino-3-iodobenzyl)-6,7-dibenzyloxy-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinoline

There total 9 articles about 1-(4-Benzoylamino-3-iodobenzyl)-6,7-dibenzyloxy-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 98-88-4
benzoyl chloride

: 180623-56-7
1-(4-Amino-3-iodobenzyl)-6,7-dibenzyloxy-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinoline

: 180623-79-4
1-(4-Benzoylamino-3-iodobenzyl)-6,7-dibenzyloxy-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With triethylamine; In dichloromethane;
DOI:10.1021/jm960208o

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 180623-79-4
1-(4-Benzoylamino-3-iodobenzyl)-6,7-dibenzyloxy-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / 1N aq. NaOH / tetrahydrofuran / Ambient temperature

2: 71 percent / H₂ / Raney Ni / 3 h / 20 °C / 2585.7 Torr

3: 81 percent / benzyltrimethylammonium dichloroiodate, CaCO₃ / methanol; CH₂Cl₂

4: 76 percent / Et₃N / CH₂Cl₂

With sodium hydroxide; hydrogen; N,N,N-trimethylbenzenemethanaminium dichloroiodate; triethylamine; calcium carbonate; nickel; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm960208o

Reference yield:

: 104-03-0
4-nitrobenzeneacetic acid

: 180623-79-4
1-(4-Benzoylamino-3-iodobenzyl)-6,7-dibenzyloxy-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 7 steps

1: toluene / 72 h / Heating

2: POCl₃ / acetonitrile / Heating

3: NaBH₄ / methanol / Ambient temperature

4: 86 percent / 1N aq. NaOH / tetrahydrofuran / Ambient temperature

5: 71 percent / H₂ / Raney Ni / 3 h / 20 °C / 2585.7 Torr

6: 81 percent / benzyltrimethylammonium dichloroiodate, CaCO₃ / methanol; CH₂Cl₂

7: 76 percent / Et₃N / CH₂Cl₂

With sodium hydroxide; sodium tetrahydroborate; hydrogen; N,N,N-trimethylbenzenemethanaminium dichloroiodate; triethylamine; calcium carbonate; trichlorophosphate; nickel; In tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile;
DOI:10.1021/jm960208o