2,2,2-Trifluoro-N-(2-methylpropyl)acetamide

Base Information

• Chemical Name: 2,2,2-Trifluoro-N-(2-methylpropyl)acetamide
• CAS No.: 1817-28-3
• Molecular Formula: C6H10F3NO
• Molecular Weight: 169.147
• Hs Code.: 2924199090
• Mol file: 1817-28-3.mol

Synonyms:N-Isobutyl-trifluoracetamid;N-Isobutyltrifluoroacetamide;Acetamide,2,2,2-trifluoro-N-isobutyl;

Chemical Property of 2,2,2-Trifluoro-N-(2-methylpropyl)acetamide

Chemical Property:

• PSA: 32.59000
• LogP: 2.16120

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,2,2-TRIFLUORO-N-(2-METHYLPROPYL)ACETAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2,2-Trifluoro-N-(2-methylpropyl)acetamide

There total 3 articles about 2,2,2-Trifluoro-N-(2-methylpropyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2,2-Trifluoro-N-hydroxy-N-isobutyl-acetamide (13628-00-7) → N-Isobutyltrifluoroacetamide (1817-28-3)

Guidance literature:

With hydrogen; nickel; In ethanol; under 76000 Torr;

DOI:10.1007/BF01151364

Reference yield:

2,2,2-Trifluoro-N-hydroxy-N-(2-methyl-allyl)-acetamide (13627-97-9) → N-Isobutyltrifluoroacetamide (1817-28-3)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd-C / ethanol / Ambient temperature

2: H₂ / Raney-Ni / ethanol / 76000 Torr

With hydrogen; palladium on activated charcoal; nickel; In ethanol;

DOI:10.1007/BF01151364

Reference yield:

isobutylamine (78-81-9) + trifluoroacetic anhydride (407-25-0) → N-Isobutyltrifluoroacetamide (1817-28-3)

Guidance literature:

In diethyl ether;

DOI:10.1007/BF00901432

upstream raw materials:

2,2,2-Trifluoro-N-hydroxy-N-isobutyl-acetamide

isobutylamine

trifluoroacetic anhydride

2,2,2-Trifluoro-N-hydroxy-N-(2-methyl-allyl)-acetamide

Downstream raw materials:

isobutyl isothiocyanate

N-Isobutyl-4-methylbenzamide

Refernces

• 1、 True, Nancy S.,Ross, Brian D.. "Conformations and Vibrational Dynamics of Six Monoalkyltrifluoroacetamides. Low-Resolution Microwave and Gas-Phase NMR Spectroscopic Studies". . p. 3216 - 3220. Retrieved 2007/10/02.