5,8-Dioxa-2,11-diazatridecanoic acid, 13-[4-[(diethoxyphosphinyl)oxy]phenyl]-13-fluoro-12-oxo-, 1,1-dimethylethyl ester

Base Information

Chemical Name:5,8-Dioxa-2,11-diazatridecanoic acid, 13-[4-[(diethoxyphosphinyl)oxy]phenyl]-13-fluoro-12-oxo-, 1,1-dimethylethyl ester
CAS No.:182227-47-0
Molecular Formula:C23H38FN2O9P
Molecular Weight:536.535
Hs Code.:
Mol file:182227-47-0.mol

Synonyms:

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Chemical Property of 5,8-Dioxa-2,11-diazatridecanoic acid, 13-[4-[(diethoxyphosphinyl)oxy]phenyl]-13-fluoro-12-oxo-, 1,1-dimethylethyl ester

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Technology Process of 5,8-Dioxa-2,11-diazatridecanoic acid, 13-[4-[(diethoxyphosphinyl)oxy]phenyl]-13-fluoro-12-oxo-, 1,1-dimethylethyl ester

There total 7 articles about 5,8-Dioxa-2,11-diazatridecanoic acid, 13-[4-[(diethoxyphosphinyl)oxy]phenyl]-13-fluoro-12-oxo-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 182227-50-5
{2-[2-(2-{2-[4-(Diethoxy-phosphoryloxy)-phenyl]-2-hydroxy-acetylamino}-ethoxy)-ethoxy]-ethyl}-carbamic acid tert-butyl ester

: 182227-47-0
{2-[2-(2-{2-[4-(Diethoxy-phosphoryloxy)-phenyl]-2-fluoro-acetylamino}-ethoxy)-ethoxy]-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: With 4,4'-diaminostilbene-2,2'-disulfonic acid; In dichloromethane; for 2h;
DOI:10.1016/S0040-4039(03)00348-4

Reference yield:

: 929-59-9,892154-56-2
3,6-dioxa-1,8-diaminooctane

: 182227-47-0
{2-[2-(2-{2-[4-(Diethoxy-phosphoryloxy)-phenyl]-2-fluoro-acetylamino}-ethoxy)-ethoxy]-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / CH₂Cl₂ / 24 h / 20 °C

2: 80 percent / EDC; HOBt / dimethylformamide / 2 h / 20 °C

3: 80 percent / CH₂Cl₂ / 24 h

4: 80 percent / DAST / CH₂Cl₂ / 2 h

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 4,4'-diaminostilbene-2,2'-disulfonic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(03)00348-4

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 182227-47-0
{2-[2-(2-{2-[4-(Diethoxy-phosphoryloxy)-phenyl]-2-fluoro-acetylamino}-ethoxy)-ethoxy]-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / CH₂Cl₂ / 24 h / 20 °C

2: 80 percent / EDC; HOBt / dimethylformamide / 2 h / 20 °C

3: 80 percent / CH₂Cl₂ / 24 h

4: 80 percent / DAST / CH₂Cl₂ / 2 h

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 4,4'-diaminostilbene-2,2'-disulfonic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(03)00348-4