phosphoric acid 4-({2-[2-(2-amino-ethoxy)-ethoxy]-ethylcarbamoyl}-fluoro-methyl)-phenyl ester diethyl ester

Base Information

Chemical Name:phosphoric acid 4-({2-[2-(2-amino-ethoxy)-ethoxy]-ethylcarbamoyl}-fluoro-methyl)-phenyl ester diethyl ester
CAS No.:570391-82-1
Molecular Formula:C₁₈H₃₀FN₂O₇P
Molecular Weight:436.418
Hs Code.:

Synonyms:phosphoric acid 4-({2-[2-(2-amino-ethoxy)-ethoxy]-ethylcarbamoyl}-fluoro-methyl)-phenyl ester diethyl ester

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Chemical Property of phosphoric acid 4-({2-[2-(2-amino-ethoxy)-ethoxy]-ethylcarbamoyl}-fluoro-methyl)-phenyl ester diethyl ester

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Technology Process of phosphoric acid 4-({2-[2-(2-amino-ethoxy)-ethoxy]-ethylcarbamoyl}-fluoro-methyl)-phenyl ester diethyl ester

There total 7 articles about phosphoric acid 4-({2-[2-(2-amino-ethoxy)-ethoxy]-ethylcarbamoyl}-fluoro-methyl)-phenyl ester diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 182227-47-0
{2-[2-(2-{2-[4-(Diethoxy-phosphoryloxy)-phenyl]-2-fluoro-acetylamino}-ethoxy)-ethoxy]-ethyl}-carbamic acid tert-butyl ester

: 570391-82-1
phosphoric acid 4-({2-[2-(2-amino-ethoxy)-ethoxy]-ethylcarbamoyl}-fluoro-methyl)-phenyl ester diethyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1016/S0040-4039(03)00348-4

Reference yield:

: 929-59-9,892154-56-2
3,6-dioxa-1,8-diaminooctane

: 570391-82-1
phosphoric acid 4-({2-[2-(2-amino-ethoxy)-ethoxy]-ethylcarbamoyl}-fluoro-methyl)-phenyl ester diethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / CH₂Cl₂ / 24 h / 20 °C

2: 80 percent / EDC; HOBt / dimethylformamide / 2 h / 20 °C

3: 80 percent / CH₂Cl₂ / 24 h

4: 80 percent / DAST / CH₂Cl₂ / 2 h

5: 90 percent / TFA / CH₂Cl₂ / 24 h / 20 °C

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 4,4'-diaminostilbene-2,2'-disulfonic acid; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(03)00348-4

Reference yield:

: 1198-84-1
4-hydroxymandelic acid

: 570391-82-1
phosphoric acid 4-({2-[2-(2-amino-ethoxy)-ethoxy]-ethylcarbamoyl}-fluoro-methyl)-phenyl ester diethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / EDC; HOBt / dimethylformamide / 2 h / 20 °C

2: 80 percent / CH₂Cl₂ / 24 h

3: 80 percent / DAST / CH₂Cl₂ / 2 h

4: 90 percent / TFA / CH₂Cl₂ / 24 h / 20 °C

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 4,4'-diaminostilbene-2,2'-disulfonic acid; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(03)00348-4