Boronic acid, [3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-

Base Information

• Chemical Name: Boronic acid, [3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-
• CAS No.: 182344-15-6
• Molecular Formula: C14H23BO3
• Molecular Weight: 250.146
• Mol file: 182344-15-6.mol

Synonyms:4-hydroxy-3,5-(t-butyl)phenylboronic acid;3,5-di-tert-butyl-4-hydroxyphenylboronic acid;3,5-di-tert-buty-4-hydroxyphenylboronic acid;3,5-di-tertbutyl-4-hydroxyphenylboronic acid;

Chemical Property of Boronic acid, [3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-

Chemical Property:

• PSA: 60.69000
• LogP: 1.66700

Purity/Quality:

97% ^*data from raw suppliers

(3,5-Di-tert-butyl-4-hydroxyphenyl)boronicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boronic acid, [3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-

There total 5 articles about Boronic acid, [3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

Trimethyl borate (121-43-7,63156-11-6) + 4-bromo-2,6-di-tert-butylphenol (1139-52-2) → (3,5-di-tert-butyl-4-hydroxyphenyl)boronic acid (182344-15-6)

Guidance literature:

4-bromo-2,6-di-tert-butylphenol; With tert.-butyl lithium; In tetrahydrofuran; pentane; at 20 ℃; for 1h; Inert atmosphere;

Trimethyl borate; In tetrahydrofuran; pentane; at -78 - 20 ℃; for 3.5h; Inert atmosphere;

DOI:10.1002/chem.201304256

Reference yield: 45.0%

4-bromo-2,6-di-tert-butylphenol (1139-52-2) → (3,5-di-tert-butyl-4-hydroxyphenyl)boronic acid (182344-15-6)

Guidance literature:

4-bromo-2,6-di-tert-butylphenol; With tert.-butyl lithium; In tetrahydrofuran; hexane; at 25 ℃; for 1h;

With Triisopropyl borate; In tetrahydrofuran; hexane; at 25 ℃; for 12h;

DOI:10.1016/j.tet.2006.01.090

Reference yield: 23.0%

Triisopropyl borate (5419-55-6) + 4-bromo-2,6-di-tert-butylphenol (1139-52-2) → (3,5-di-tert-butyl-4-hydroxyphenyl)boronic acid (182344-15-6)

Guidance literature:

4-bromo-2,6-di-tert-butylphenol; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃;

Triisopropyl borate; In tetrahydrofuran; hexane; at -78 - 20 ℃;

With ammonium chloride; In tetrahydrofuran; hexane; at 20 ℃; for 2h;

upstream raw materials:

4-bromo-2,6-di-tert-butylphenol

Triisopropyl borate

Trimethyl borate

Downstream raw materials:

1,2-bis(3,5-di-tert-butyl-4-hydroxyphenyl)acenaphthylene

1-(cyclohexylmethyl)-5-(3,5-di-tert-butyl-4-hydroxyphenyl)-1H-1,2,4-triazole-3-carboxamide

C₃₆H₄₆O₂S₂