(4R)-1-Acetyl-4-(benzyloxy)-L-proline

Base Information

Chemical Name:(4R)-1-Acetyl-4-(benzyloxy)-L-proline
CAS No.:182964-78-9
Molecular Formula:C14H17NO4
Molecular Weight:263.293
Hs Code.:
DSSTox Substance ID:DTXSID00705689
Wikidata:Q82638666

Synonyms:182964-78-9;(4R)-1-Acetyl-4-(benzyloxy)-L-proline;SCHEMBL5635255;DTXSID00705689

Suppliers and Price of (4R)-1-Acetyl-4-(benzyloxy)-L-proline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of (4R)-1-Acetyl-4-(benzyloxy)-L-proline

Chemical Property:

XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:263.11575802
Heavy Atom Count:19
Complexity:338

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)N1CC(CC1C(=O)O)OCC2=CC=CC=C2
Isomeric SMILES:CC(=O)N1C[C@@H](C[C@H]1C(=O)O)OCC2=CC=CC=C2

Technology Process of (4R)-1-Acetyl-4-(benzyloxy)-L-proline

There total 3 articles about (4R)-1-Acetyl-4-(benzyloxy)-L-proline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 676596-53-5
Ac-Hyp(OBzl)-OMe

: 182964-78-9
trans-1-acetyl-4-benzyloxy-L-proline

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; at 0 ℃; for 0.5h;
DOI:10.1021/jm030050p

Reference yield:

: 66831-17-2
(2S,4R)-methyl 4-(benzyloxy)pyrrolidine-2-carboxylate hydrochloride

: 182964-78-9
trans-1-acetyl-4-benzyloxy-L-proline

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / triethylamine; pyridine / 16.5 h / 0 - 20 °C

2: 73 percent / aq. LiOH / tetrahydrofuran / 0.5 h / 0 °C

With pyridine; lithium hydroxide; triethylamine; In tetrahydrofuran;
DOI:10.1021/jm030050p

Reference yield:

: 113490-76-9
4(R)-(phenylmethoxy)-(S)-proline methyl ester

: 182964-78-9
trans-1-acetyl-4-benzyloxy-L-proline

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine

2: NaOH / methanol

With pyridine; sodium hydroxide; In methanol;
DOI:10.1016/0960-894X(96)00404-0