1-(3,4-Dimethoxyphenyl)-2-phenoxyethanol

Base Information

Chemical Name:1-(3,4-Dimethoxyphenyl)-2-phenoxyethanol
CAS No.:183303-74-4
Molecular Formula:C16H18O4
Molecular Weight:274.317
Hs Code.:
DSSTox Substance ID:DTXSID401249734
Nikkaji Number:J755.060J

Synonyms:1-(3,4-dimethoxyphenyl)-2-phenoxyethanol;183303-74-4;DTXSID401249734;AKOS009160730;BS-46452;CS-0163188;E75219;3,4-Dimethoxy-alpha-(phenoxymethyl)benzenemethanol

Suppliers and Price of 1-(3,4-Dimethoxyphenyl)-2-phenoxyethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 1-(3,4-Dimethoxyphenyl)-2-phenoxyethanol

Chemical Property:

XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:274.12050905
Heavy Atom Count:20
Complexity:265

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C=C1)C(COC2=CC=CC=C2)O)OC

Technology Process of 1-(3,4-Dimethoxyphenyl)-2-phenoxyethanol

There total 13 articles about 1-(3,4-Dimethoxyphenyl)-2-phenoxyethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 140455-40-9
1-(3,4-dimethoxyphenyl)-2-phenoxy-1-ethanone

: 183303-74-4
1-(3,4-dimethoxyphenyl)-2-phenoxy-1-ethanol

Guidance literature:: With sodium tetrahydroborate; In methanol; for 2h;
DOI:10.1039/b101362i

Reference yield:

: 1835-02-5
2-Bromo-1-(3,4-dimethoxyphenyl)ethanone

: 108-95-2,27073-41-2
phenol

: 183303-74-4
1-(3,4-dimethoxyphenyl)-2-phenoxy-1-ethanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / acetone / 0.5 h / 20 °C

1.2: 3 h / Reflux

2.1: sodium tetrahydroborate / tetrahydrofuran; water / 3 h / 20 °C

With sodium tetrahydroborate; potassium carbonate; In tetrahydrofuran; water; acetone;
DOI:10.1002/anie.202008261

Reference yield:

: 721-04-0
2-phenoxy-1-phenylethanone

: 183303-74-4
1-(3,4-dimethoxyphenyl)-2-phenoxy-1-ethanol

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate / tetrahydrofuran; water / 6 h / 20 °C

2: palladium 10% on activated carbon; sodium formate / toluene / 12 h / 150 °C / Inert atmosphere

3: potassium carbonate / acetone / 5 h / 20 °C

4: sodium tetrahydroborate / tetrahydrofuran; water / 6 h / 20 °C

With sodium tetrahydroborate; palladium 10% on activated carbon; sodium formate; potassium carbonate; In tetrahydrofuran; water; acetone; toluene;
DOI:10.1016/j.cclet.2021.08.125