4-(2,5-Dichlorophenyl)-1,3-thiazol-2-amine

Base Information

• Chemical Name: 4-(2,5-Dichlorophenyl)-1,3-thiazol-2-amine
• CAS No.: 68301-45-1
• Molecular Formula: C9H6Cl2N2S
• Molecular Weight: 245.132
• Hs Code.: 2934100090
• European Community (EC) Number: 858-134-8
• DSSTox Substance ID: DTXSID00366416
• Nikkaji Number: J2.473.258D
• Wikidata: Q82151622
• Mol file: 68301-45-1.mol

Synonyms:68301-45-1;4-(2,5-dichlorophenyl)-1,3-thiazol-2-amine;2-Amino-4-(2,5-dichlorophenyl)thiazole;4-(2,5-dichlorophenyl)thiazol-2-amine;4-(2,5-Dichloro-phenyl)-thiazol-2-ylamine;4-(2,5-dichlorophenyl)thiazol-2-ylamine;2-Thiazolamine, 4-(2,5-dichlorophenyl)-;MFCD02664023;SCHEMBL1800878;DTXSID00366416;BBL017197;STK441958;AKOS000122259;4-(2,5-dichlorophenyl)-2-thiazolamine;AS-31723;SY012605;CS-0071380;4-(2,5-Dichloro-phenyl)- thiazol-2-ylamine;EN300-02219;A836090;J-513264;4-[2,5-bis(chloranyl)phenyl]-1,3-thiazol-2-amine;Z48847514;F2146-0028

Chemical Property of 4-(2,5-Dichlorophenyl)-1,3-thiazol-2-amine

Chemical Property:

• Vapor Pressure: 1.59E-06mmHg at 25°C
• Boiling Point: 397.4°Cat760mmHg
• Flash Point: 194.2°C
• PSA: 67.15000
• Density: 1.498g/cm³
• LogP: 4.28030
• Storage Temp.: 2-8°C
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 243.9628748
• Heavy Atom Count: 14
• Complexity: 205

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-4-(2,5-dichlorophenyl)thiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1Cl)C2=CSC(=N2)N)Cl
• Uses: 2-Amino-4-(2,5-dichlorophenyl)thiazole is a useful intermediate for organic synthesis and other chemical and pharmaceutical processes.

Technology Process of 4-(2,5-Dichlorophenyl)-1,3-thiazol-2-amine

There total 4 articles about 4-(2,5-Dichlorophenyl)-1,3-thiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-bromo-1-(2,5-dichlorophenyl)ethanone (4571-25-9) + thiourea (17356-08-0) → 4-(2,5-dichlorophenyl)-1,3-thiazol-2-amine (68301-45-1)

Guidance literature:

In ethanol; at 80 ℃; for 0.333333h; Microwave irradiation;

DOI:10.1080/10426500802715163

Reference yield: 96.0%

2,5-dichloroacetophenone (2476-37-1) + thiourea (17356-08-0) → 4-(2,5-dichlorophenyl)-1,3-thiazol-2-amine (68301-45-1)

Guidance literature:

With iodine; for 4h; Heating;

Reference yield: 76.0%

C8H5Cl2N3 + ammonium thiocyanate (1147550-11-5) → 4-(2,5-dichlorophenyl)-1,3-thiazol-2-amine (68301-45-1)

Guidance literature:

With copper diacetate; In acetonitrile; at 20 ℃; for 20h; Irradiation; Inert atmosphere;

DOI:10.1021/acscatal.7b02818

upstream raw materials:

2-bromo-1-(2,5-dichlorophenyl)ethanone

thiourea

2,5-dichloroacetophenone

ammonium thiocyanate

Downstream raw materials:

4-(2,5-Dichloro-phenyl)-5-(2,2-dimethyl-chroman-6-ylazo)-thiazol-2-ylamine

4-amino-N-[4-(2,5-dichloro-phenyl)-thiazol-2-yl]-benzenesulfonamide

4-(2,5-dichloro-phenyl)-5-nitro-thiazol-2-ylamine

N-[4-(2,5-dichlorophenyl)-1,3-thiazol-2-yl]-2-[4-(ethylsulfonyl)phenyl]acetamide