2476-37-1

Basic information

• Product Name: 2',5'-Dichloroacetophenone
• Synonyms: 2',5'-DICHLOROACETOPHENONE;2,5-DICHLOROACETOPHENONE;1-(2,5-DICHLOROPHENYL)ETHANONE;1-(2,5-dichlorophenyl)-ethanon;Acetophenone, 2',5'-dichloro-;Ethanone, 1-(2,5-dichlorophenyl)-;2',5'-Dichloroacetophenone 1-(2,5-Dichlorophenyl)ethanone;1-(2,5-Dichlorophenyl)ethan-1-one
• CAS NO: 2476-37-1
• Molecular Formula: C₈H₆Cl₂O
• Molecular Weight: 189.04
• EINECS: 219-605-8
• Product Categories: Acetophenone Series;Carbonyl Compounds;Halides;Aromatic Acetophenones & Derivatives (substituted);Adehydes, Acetals & Ketones;Chlorine Compounds;C7 to C8;Carbonyl Compounds;Ketones
• Mol File: 2476-37-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 11-13 °C(lit.)
• Boiling Point: 118 °C (12 mmHg)
• Flash Point: >230 °F
• Appearance: Clear yellow to brownish/Liquid
• Density: 1.312 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.5624(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• BRN: 1865043
• CAS DataBase Reference: 2',5'-Dichloroacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2',5'-Dichloroacetophenone(2476-37-1)
• EPA Substance Registry System: 2',5'-Dichloroacetophenone(2476-37-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/38-36/37/38
• Safety Statements: 24/25-36-26-37-23
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 2476-37-1(Hazardous Substances Data)

Usage

Chemical Properties

clear yellow to brownish liquid

Uses

2′,5′-Dichloroacetophenone was used in the synthesis of 5-chloro-2-(2-thienylthio)acetophenone.

General Description

The standard molar enthalpy of formation of 2′,5′-dichloroacetophenone in the condensed phase was studied.

Upstream product

• 38417-89-9 (2,5-dichlorophenyl)acetylene 
• 75-16-1 methylmagnesium bromide 
• 50-79-3 2,5-dichlorobenzoic acid 
• 95-82-9 2,5 dichloroaniline 
• 4571-25-9 2-bromo-1-(2,5-dichlorophenyl)ethanone 
• 98-86-2 acetophenone 
• 106-46-7 para-dichlorobenzene 
• 75-36-5 acetyl chloride 
• 917-64-6 methyl magnesium iodide 
• 21663-61-6 2,5-dichlorobenzonitrile 

Downstream Products

• 67643-08-7 4-[(2,5-dichloro-phenyl)-thioacetyl]-morpholine 
• 62436-53-7 2-(2,5-dichloro-phenyl)-propan-2-ol 
• 107165-40-2 5-Chloro-2-(3-chlorophenylthio)acetophenone 
• 40587-09-5 1-(2,5-Dichloro-phenyl)-2-methylamino-ethanol 
• 851707-81-8 2,5-dichloro-α-tosyloxyacetophenone 
• 108059-62-7 2-(2-Acetyl-4-chlorphenylthio)benzoesaeure-methylester 
• 13420-71-8 2-<5-chloro-2-(4-chlorophenylthio)phenyl>acetic acid 
• 107165-02-6 (5-Chloro-2-(2-methylphenylthio)phenyl)acetic Acid 
• 107165-44-6 (5-Chloro-2-(3-chlorophenylthio)phenyl)acetic Acid 
• 107165-43-5 (5-Chloro-2-(2-chlorophenylthio)phenyl)acetic Acid 
• 86759-13-9 2-<5-chloro-2-(4-chlorophenylthio)phenyl>acetic acid thiomorpholide 
• 107165-42-4 (5-Chloro-2-(3-chlorophenylthio)phenyl)acetothiomorpholide 
• 107165-00-4 (5-Chloro-2-(2-methylphenylthio)phenyl)acetic Acid Thiomorpholide 
• 86759-14-0 5-chloro-2-(4-chlorophenylthio)phenylglyoxylic acid thiomorpholide 

Relevant articles and documents

Irsogladine maleate preparation method

The invention belongs to the field of organic matter synthesis, and particularly relates to an irsogladine maleate preparation method, wherein p-dichlorobenzene is used as a starting raw material, andfive reactions of acetylation, bromoform reaction, cyanation, cyclization and salt formation are performed to prepare the target compound. According to the present invention, the new irsogladine maleate preparation method is used, can significantly accelerate the reaction rate and improve the yield, has advantages of cost reducing, environment protection, simple operation and convenient post-treatment, and is suitable for industrial production.

One-pot synthesis of chiral alcohols from alkynes by CF3SO3H/ruthenium tandem catalysis

A practical one-pot synthesis of chiral alcohols from readily available alkynes via tandem catalysis by the combination of CF3SO3H and a fluorinated chiral diamine Ru(ii) complex in aqueous CF3CH2OH is described. Very interestingly, the combination of fluorinated catalysts and solvent exhibits a positive fluorine effect on the reactivity and enantioselectivity. A range of chiral alcohols with wide functional group tolerance was obtained in high yield and excellent stereoselectivity under simple and mild conditions.

Microwave-assisted dehalogenation of α-haloketones by zinc and ammonium chloride in alcohol

The treatment of α-haloketones with 1.5 equiv. of Zn and 1 equiv. of NH4Cl in ethanol for 0.5αmin gave the corresponding ketones with excellent yields under microwave irradiation. Vic-dibromides and 2,2-dibromoacetophenone can be efficiently debrominated to alkenes and acetophenones, respectively. Copyright Taylor & Francis Group, LLC.