5-BROMO-1,3-DIMETHYLURACIL

Base Information

• Chemical Name: 5-BROMO-1,3-DIMETHYLURACIL
• CAS No.: 7033-39-8
• Molecular Formula: C6H7BrN2O2
• Molecular Weight: 219.038
• Hs Code.: 2933599090
• Mol file: 7033-39-8.mol

Synonyms:Uracil,5-bromo-1,3-dimethyl- (6CI,7CI,8CI);1,3-Dimethyl-5-bromouracil;5-Bromo-1,3-dimethyl-1H-pyrimidine-2,4-dione;5-Bromo-1,3-dimethyluracil;

Chemical Property of 5-BROMO-1,3-DIMETHYLURACIL

Chemical Property:

• Vapor Pressure: 0.0346mmHg at 25°C
• Melting Point: 182-185 °C(lit.)
• Refractive Index: 1.585
• Boiling Point: 242.1 °C at 760 mmHg
• PKA: -3.81±0.40(Predicted)
• Flash Point: 100.2 °C
• PSA: 44.00000
• Density: 1.721 g/cm³
• LogP: -0.15350
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Bromo-1,3-dimethyluracil ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 5-BROMO-1,3-DIMETHYLURACIL

There total 19 articles about 5-BROMO-1,3-DIMETHYLURACIL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1,3-dimethyluracil (874-14-6,156398-76-4) → 5-bromo-1,3-dimethyluracil (7033-39-8)

Guidance literature:

With Bromoform; In dichloromethane; for 4h; Irradiation;

Reference yield: 84.5%

5,5'-mercuribis(1,3-dimethyluracil) (119255-07-1) → 5-bromo-1,3-dimethyluracil (7033-39-8)

Guidance literature:

With bromine; potassium bromide; at 80 ℃; for 0.5h;

Reference yield: 83.0%

1,3-dimethyl-2-thiouracil (1194-71-4) → 5-bromo-1,3-dimethyluracil (7033-39-8) + 5-bromo-1,3-dimethyl-2-thiouracil

Guidance literature:

With Bromoform; oxygen; at 90 ℃; for 16h;

upstream raw materials:

1,3-dimethyluracil

tert.-butylhydroperoxide

3-chloro-benzenecarboperoxoic acid

5-bromouracil

Downstream raw materials:

1,3-dimethyl-5-(3-methyl-1H-indol-2-yl)uracil

1,3-dimethyluracil

1,3-dimethyl-5-(2,5-dimethylphenyl)uracil

1,3-dimethyl-6-(2,5-dimethylphenyl)uracil

Refernces

• 1、 Fosu, Stacy C.,Hambira, Chido M.,Chen, Andrew D.,Fuchs, James R.,Nagib, David A.. "Site-Selective C–H Functionalization of (Hetero)Arenes via Transient, Non-symmetric Iodanes". supporting information. p. 417 - 428. Retrieved 2019/02/14.
• 2、 Lee, Hyun Seung,Lee, Hyun Ju,Lee, Ka Young,Kim, Jae Nyoung. "Controlled C-5 chlorination and dichlorohydrin formation of uracil ring with HCl/DMF/Oxone system". experimental part. p. 1357 - 1359. Retrieved 2012/07/13.