tert-butyl 3-(4-fluorophenyl)-1-hydroxypropan-2-ylcarbamate

Base Information

• Chemical Name: tert-butyl 3-(4-fluorophenyl)-1-hydroxypropan-2-ylcarbamate
• CAS No.: 183669-12-7
• Molecular Formula: C14H20FNO3
• Molecular Weight: 269.31200
• Mol file: 183669-12-7.mol

Synonyms:[2-(4-Fluoro-phenyl)-1-hydroxymethyl-ethyl]-carbamic acid tert-butyl ester;N-(t-butyloxycarbonyl)-p-fluorophenylalaninol;

Chemical Property of tert-butyl 3-(4-fluorophenyl)-1-hydroxypropan-2-ylcarbamate

Chemical Property:

• PSA: 58.56000
• LogP: 2.64470

Purity/Quality:

tert-butyl3-(4-fluorophenyl)-1-hydroxypropan-2-ylcarbamate 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 3-(4-fluorophenyl)-1-hydroxypropan-2-ylcarbamate

There total 2 articles about tert-butyl 3-(4-fluorophenyl)-1-hydroxypropan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-amino-3-(4-fluorophenyl) propanoate (59850-77-0,73283-54-2) → D,L-N-(tert-butoxycarbonyl)-p-fluorophenylalaninol (183669-12-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 50 percent / LiCl, NaBH₄ / tetrahydrofuran; ethanol / 3 h / 50 - 55 °C

2: CH₂Cl₂ / 2 h / Ambient temperature

With sodium tetrahydroborate; lithium chloride; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1021/jm00033a008

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 2-amino-3-(4-fluorophenyl)propan-1-ol (35373-69-4,200267-65-8,348619-91-0,64230-78-0) → D,L-N-(tert-butoxycarbonyl)-p-fluorophenylalaninol (183669-12-7)

Guidance literature:

In dichloromethane; for 2h; Ambient temperature;

DOI:10.1021/jm00033a008

Reference yield: 98.0%

D,L-N-(tert-butoxycarbonyl)-p-fluorophenylalaninol (183669-12-7) + methyl iodide (74-88-4) → [2-(4-Fluoro-phenyl)-1-methoxymethyl-ethyl]-carbamic acid tert-butyl ester (155392-42-0)

Guidance literature:

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In tetrahydrofuran; Ambient temperature;

DOI:10.1021/jm00033a008

upstream raw materials:

di-tert-butyl dicarbonate

2-amino-3-(4-fluorophenyl)propan-1-ol

ethyl 2-amino-3-(4-fluorophenyl) propanoate

Downstream raw materials:

[1-Ethoxymethyl-2-(4-fluoro-phenyl)-ethyl]-carbamic acid tert-butyl ester

[2-(4-Fluoro-phenyl)-1-propoxymethyl-ethyl]-carbamic acid tert-butyl ester

[2-(4-Fluoro-phenyl)-1-methoxymethyl-ethyl]-carbamic acid tert-butyl ester

D,L-4-fluorophenylalaninyl methyl ether