Ethanone, 2-[4-(2-methoxyphenyl)-1-piperazinyl]-1-[3-(2-phenylethyl)-2-benzofuran yl]-

Base Information

• Chemical Name: Ethanone, 2-[4-(2-methoxyphenyl)-1-piperazinyl]-1-[3-(2-phenylethyl)-2-benzofuran yl]-
• CAS No.: 183883-07-0
• Molecular Formula: C29H30N2O3
• Molecular Weight: 454.569
• Mol file: 183883-07-0.mol

Synonyms:

Chemical Property of Ethanone, 2-[4-(2-methoxyphenyl)-1-piperazinyl]-1-[3-(2-phenylethyl)-2-benzofuran yl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethanone, 2-[4-(2-methoxyphenyl)-1-piperazinyl]-1-[3-(2-phenylethyl)-2-benzofuran yl]-

There total 11 articles about Ethanone, 2-[4-(2-methoxyphenyl)-1-piperazinyl]-1-[3-(2-phenylethyl)-2-benzofuran yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2'-hydroxy-3-phenylpropiophenone (3516-95-8) → 2-[4-(2-methoxyphenyl)-1-piperazinyl]-1-[3-(2-phenylethyl)-2-benzofuryl]ethanone (183883-07-0)

Guidance literature:

Multi-step reaction with 6 steps

1: NaOH

2: conc. HCl

3: oxalyl chloride, DMSO

4: SiO₂

5: H₃PO₄

6: toluene / 5 h / 60 °C

With hydrogenchloride; sodium hydroxide; oxalyl dichloride; phosphoric acid; silica gel; dimethyl sulfoxide; In toluene;

DOI:10.1021/jm960384x

Reference yield:

1-(2-(oxiran-2-ylmethoxy)phenyl)-3-phenylpropan-1-one (22525-95-7) → 2-[4-(2-methoxyphenyl)-1-piperazinyl]-1-[3-(2-phenylethyl)-2-benzofuryl]ethanone (183883-07-0)

Guidance literature:

Multi-step reaction with 5 steps

1: conc. HCl

2: oxalyl chloride, DMSO

3: SiO₂

4: H₃PO₄

5: toluene / 5 h / 60 °C

With hydrogenchloride; oxalyl dichloride; phosphoric acid; silica gel; dimethyl sulfoxide; In toluene;

DOI:10.1021/jm960384x

Reference yield:

2-Chlor-1-(2,3-dihydro-3-hydroxy-3-(2-phenylethyl)benzofuran-2-yl)ethanon (165279-81-2) → 2-[4-(2-methoxyphenyl)-1-piperazinyl]-1-[3-(2-phenylethyl)-2-benzofuryl]ethanone (183883-07-0)

Guidance literature:

Multi-step reaction with 2 steps

1: H₃PO₄

2: toluene / 5 h / 60 °C

With phosphoric acid; In toluene;

DOI:10.1021/jm960384x

upstream raw materials:

2'-hydroxy-3-phenylpropiophenone

1-(2-(oxiran-2-ylmethoxy)phenyl)-3-phenylpropan-1-one

3-(2-phenylethyl)benzofuran

2-Chlor-1-(2,3-dihydro-3-hydroxy-3-(2-phenylethyl)benzofuran-2-yl)ethanon