2-Chlor-1-(2,3-dihydro-3-hydroxy-3-(2-phenylethyl)benzofuran-2-yl)ethanon

Base Information

• Chemical Name: 2-Chlor-1-(2,3-dihydro-3-hydroxy-3-(2-phenylethyl)benzofuran-2-yl)ethanon
• CAS No.: 165279-81-2
• Molecular Formula: C₁₈H₁₇ClO₃
• Molecular Weight: 316.784
• Mol file: 165279-81-2.mol

Synonyms:2-Chlor-1-(2,3-dihydro-3-hydroxy-3-(2-phenylethyl)benzofuran-2-yl)ethanon

Chemical Property of 2-Chlor-1-(2,3-dihydro-3-hydroxy-3-(2-phenylethyl)benzofuran-2-yl)ethanon

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Chlor-1-(2,3-dihydro-3-hydroxy-3-(2-phenylethyl)benzofuran-2-yl)ethanon

There total 4 articles about 2-Chlor-1-(2,3-dihydro-3-hydroxy-3-(2-phenylethyl)benzofuran-2-yl)ethanon which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-Chlor-3-(2-(3-phenylpropionyl)phenyloxy)aceton (165279-80-1) → 2-Chlor-1-(2,3-dihydro-3-hydroxy-3-(2-phenylethyl)benzofuran-2-yl)ethanon (165279-81-2)

Guidance literature:

With silica gel; In diethyl ether; for 16h; Ambient temperature;

DOI:10.1002/ardp.19953280410

Reference yield:

2'-hydroxy-3-phenylpropiophenone (3516-95-8) → 2-Chlor-1-(2,3-dihydro-3-hydroxy-3-(2-phenylethyl)benzofuran-2-yl)ethanon (165279-81-2)

Guidance literature:

Multi-step reaction with 4 steps

1: NaOH

2: conc. HCl

3: oxalyl chloride, DMSO

4: SiO₂

With hydrogenchloride; sodium hydroxide; oxalyl dichloride; silica gel; dimethyl sulfoxide;

DOI:10.1021/jm960384x

Reference yield:

1-(2-(oxiran-2-ylmethoxy)phenyl)-3-phenylpropan-1-one (22525-95-7) → 2-Chlor-1-(2,3-dihydro-3-hydroxy-3-(2-phenylethyl)benzofuran-2-yl)ethanon (165279-81-2)

Guidance literature:

Multi-step reaction with 3 steps

1: conc. HCl

2: oxalyl chloride, DMSO

3: SiO₂

With hydrogenchloride; oxalyl dichloride; silica gel; dimethyl sulfoxide;

DOI:10.1021/jm960384x

upstream raw materials:

1-Chlor-3-(2-(3-phenylpropionyl)phenyloxy)aceton

2'-hydroxy-3-phenylpropiophenone

1-(2-(oxiran-2-ylmethoxy)phenyl)-3-phenylpropan-1-one

1-(2-(3-Chlor-2-hydroxy-propoxy)phenyl)-3-phenyl-1-propanon

Downstream raw materials:

3-(2-phenylethyl)benzofuran

1-chloro-2-(3-(2-phenyl-ethyl)-2-benzofuryl)-ethane

2-Chloro-1-(3-phenethyl-benzofuran-2-yl)-ethanone

2-[4-(2-methoxyphenyl)-1-piperazinyl]-1-[3-(2-phenylethyl)-2-benzofuryl]ethanone