1-(Chloromethyl)-4-(cyclopropylmethoxy)benzene

Base Information

Chemical Name:1-(Chloromethyl)-4-(cyclopropylmethoxy)benzene
CAS No.:183994-41-4
Molecular Formula:C11H13ClO
Molecular Weight:196.677
Hs Code.:
DSSTox Substance ID:DTXSID70598388
Wikidata:Q82494138
Mol file:183994-41-4.mol

Synonyms:1-(chloromethyl)-4-(cyclopropylmethoxy)benzene;183994-41-4;Benzene, 1-(chloromethyl)-4-(cyclopropylmethoxy)-;SCHEMBL1391126;DTXSID70598388;OQNNIWTWNXVOCF-UHFFFAOYSA-N;DA-30672;4-(cyclopropylmethoxy)phenylmethyl chloride;4-(cyclopropylmeth-oxy)phenylmethyl chloride;Benzene,1-(chloromethyl)-4-(cyclopropylmethoxy)-

Suppliers and Price of 1-(Chloromethyl)-4-(cyclopropylmethoxy)benzene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 1-(Chloromethyl)-4-(cyclopropylmethoxy)benzene

Chemical Property:

PSA：9.23000
LogP:3.21420
XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:4
Exact Mass:196.0654927
Heavy Atom Count:13
Complexity:148

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC1COC2=CC=C(C=C2)CCl

Technology Process of 1-(Chloromethyl)-4-(cyclopropylmethoxy)benzene

There total 2 articles about 1-(Chloromethyl)-4-(cyclopropylmethoxy)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 164520-99-4
4-(cyclopropylmethoxy)benzaldehyde

: 183994-41-4
4-(cyclopropylmeth-oxy)phenylmethyl chloride

Guidance literature:: 4-(cyclopropylmethoxy)benzaldehyde; With methanol; sodium tetrahydroborate; at 0 - 20 ℃; for 1h;

With thionyl chloride; In diethyl ether; at 20 ℃; for 2h;
DOI:10.1002/open.201800214

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 183994-41-4
4-(cyclopropylmeth-oxy)phenylmethyl chloride

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 24 h / Reflux

2: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C

3: thionyl chloride / diethyl ether / 2 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; thionyl chloride; potassium carbonate; In methanol; diethyl ether; acetone;
DOI:10.1002/ejoc.201501486