4-(Cyclopropylmethoxy)benzaldehyde

Base Information

• Chemical Name: 4-(Cyclopropylmethoxy)benzaldehyde
• CAS No.: 164520-99-4
• Molecular Formula: C₁₁H₁₂O₂
• Molecular Weight: 176.215
• European Community (EC) Number: 820-333-2
• DSSTox Substance ID: DTXSID80337528
• Wikidata: Q82105380
• Mol file: 164520-99-4.mol

Synonyms:4-(Cyclopropylmethoxy)benzaldehyde;164520-99-4;Benzaldehyde,-4-cyclopropylmethoxy;4-cyclopropylmethoxybenzaldehyde;SCHEMBL3718600;DTXSID80337528;4-(Cyclopropylmethoxy)benzaldehyde #;AKOS000260160;BS-50382;CS-0236990;E73984;EN300-176106;Z335440200

Chemical Property of 4-(Cyclopropylmethoxy)benzaldehyde

Chemical Property:

• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 176.083729621
• Heavy Atom Count: 13
• Complexity: 167

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CC1COC2=CC=C(C=C2)C=O

Technology Process of 4-(Cyclopropylmethoxy)benzaldehyde

There total 2 articles about 4-(Cyclopropylmethoxy)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) + cyclopropylcarbinyl bromide (7051-34-5) → 4-(cyclopropylmethoxy)benzaldehyde (164520-99-4)

Guidance literature:

With potassium carbonate; In acetone; for 48h; Heating / reflux;

Reference yield:

Cyclopropylmethanol (2516-33-8) + 4-fluorobenzaldehyde (459-57-4) → 4-(cyclopropylmethoxy)benzaldehyde (164520-99-4)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; at 80 ℃; for 8h;

DOI:10.1016/j.bmcl.2004.02.087

Reference yield: 99.0%

4-(cyclopropylmethoxy)benzaldehyde (164520-99-4) → (4-(cyclopropylmethoxy)phenyl)methanol (712313-61-6)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 1h;

DOI:10.1002/ejoc.201501486

upstream raw materials:

Cyclopropylmethanol

4-fluorobenzaldehyde

4-hydroxy-benzaldehyde

cyclopropylcarbinyl bromide

Downstream raw materials:

4-(cyclopropylmethoxy)-phenol

2-chloro-4-cyclopropylmethoxy-phenol

1-(3-bromo-propoxy)-2-chloro-4-cyclopropylmethoxy-benzene

5-(4-Cyclopropylmethoxy-benzyl)-thiazolidine-2,4-dione