Technology Process of 1,3-Dioxolane, 2,2-diethyl-4-[7-(phenylmethoxy)-3-heptynyl]-, (S)-
There total 2 articles about 1,3-Dioxolane, 2,2-diethyl-4-[7-(phenylmethoxy)-3-heptynyl]-, (S)- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: NaI, NaHCO3 / acetone / 6 h
2: 1) 1.56 M nBuLi in hexane / 1) THF, -40 deg C then 0 deg C, 40 min, 2) THF, HMPA, 0 deg C, 1 h then 1 h, RT
With
n-butyllithium; sodium hydrogencarbonate; sodium iodide;
In
acetone;
- Guidance literature:
-
With
n-butyllithium;
Yield given. Multistep reaction;
1) THF, -40 deg C then 0 deg C, 40 min, 2) THF, HMPA, 0 deg C, 1 h then 1 h, RT;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 96 percent / hydrogen / 10percent Pd/C / ethyl acetate / 12 h / Ambient temperature
2: pyridine / ) deg C, 1 h; RT, 5 h
3: 91 percent / NaI, NaHCO3 / acetone / 8 h
4: 10 0.6 m NaHMDS in toluene / 1) THF, 0 deg C, 30 min, 2) THF, toluene, HMPA, 0 deg C to RT
5: 99 percent / p-TsOH / methanol / 48 h
6: pyridine / 0 deg C, 1 h; RT, 5 h
With
pyridine; hydrogen; sodium hexamethyldisilazane; sodium hydrogencarbonate; toluene-4-sulfonic acid; sodium iodide;
palladium on activated charcoal;
In
methanol; ethyl acetate; acetone;
