57618-47-0

Basic information

• Product Name: Benzene, [(4-pentynyloxy)methyl]-
• Synonyms: O-benzyl-5-pentyn-1-ol;Pent-1-yne,5-benzyloxy;UPCMLD00WJLM60
• CAS NO: 57618-47-0
• Molecular Formula: C12H14O
• Molecular Weight: 174.243
• Mol File: 57618-47-0.mol
• Article Data: 34

Chemical Properties

• Boiling Point: 247.7±23.0 °C(Predicted)
• Density: 0.976±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Benzene, [(4-pentynyloxy)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, [(4-pentynyloxy)methyl]-(57618-47-0)
• EPA Substance Registry System: Benzene, [(4-pentynyloxy)methyl]-(57618-47-0)

Safety Data

• Hazardous Substances Data: 57618-47-0(Hazardous Substances Data)

Upstream product

• 591-50-4 iodobenzene 
• 207386-32-1 (5-(benzyloxy)pent-1-yn-1-yl)-trimethylsilane 
• 5390-04-5 pent-1-yn-5-ol 
• 100-44-7 benzyl chloride 
• 1189177-80-7 [5-(benzyloxy)pent-1-ynyl]triisopropylsilane 
• 55791-06-5 benzyl mesylate 
• 100-51-6 benzyl alcohol 
• 6089-09-4 4-pentynoic acid 
• 21565-82-2 methyl pent-4-ynoate 
• 1035808-45-7 1-[(5,5-dibromopent-4-enyloxy)methyl]benzene 
• 5470-84-8 4-benzyloxybutanal 
• 100-52-7 benzaldehyde 
• 97-99-4 Tetrahydrofurfuryl alcohol 
• 100-39-0 benzyl bromide 

Downstream Products

• 102438-16-4 6-benzyloxy-hex-2-ynoic acid methyl ester 
• 344346-05-0 (R)-8-(benzyloxy)oct-4-yn-2-ol 
• 207386-32-1 (5-(benzyloxy)pent-1-yn-1-yl)-trimethylsilane 
• 288373-10-4 5-benzyloxy-1-(p-toluenesulfonyl)-1-pentyne 
• 288372-94-1 (-)-(8R,8aS)-5-(3-benzyloxypropyl)-8-methyl-6-(p-toluenesulfonyl)-Δ^5,6-indolizidine 
• 1020401-60-8 C₁₈H₁₉NO₄S 
• 1052703-57-7 2-butyltelluro-5-benzyloxy-1-pentenyl 

Relevant articles and documents

Synthesis of novel 1,2,3-triazole derivatives of isocoumarins and 3,4-dihydroisocoumarin with potential antiplasmodial activity in vitro

Background: Malaria greatly affects the world health, having caused more than 228 million cases only in 2018. The emergence of drug resistance is one of the main problems in its treatment, dem-onstrating the need for the development of new antimalarial drugs. Objective: Synthesis and in vitro antiplasmodial evaluation of triazole compounds derived from isocou-marins and a 3,4-dihydroisocoumarin. Methods: The compounds were synthesized in 4 to 6-step reactions with the formation of the triazole ring via the Copper(I)-catalyzed 1,3-dipolar cycloaddition between isocoumarin or 3,4-dihydroisocoumarin azides and terminal alkynes. This key reaction provided compounds with an un-precedented connection of isocoumarin or 3,4-dihydroisocoumarin and the 1,2,3-triazole ring. The products were tested for their antiplasmodial activity against a Plasmodium falciparum chloroquine resistant and sensitive strains (W2 and 3D7, respectively). Results: Thirty-one substances were efficiently obtained by the proposed routes with an overall yield of 25-53%. The active substances in the antiplasmodial test displayed IC50 values ranging from 0.68-2.89 μM and 0.85-2.07 μM against W2 and 3D7 strains, respectively. Conclusion: This study demonstrated the great potential of isocoumarin or 3,4-dihydroisocoumarin derivatives because practically all the tested substances were active against Plasmodium falciparum.

3,6-DIAMINO-PYRIDAZIN-3-YL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS PRO-APOPTOTIC AGENTS

Compounds of formula (I) wherein Het1, Het2, R1, R2 and R3 are as defined in the description. Medicaments.

Fluorine in pheromones: Synthesis of fluorinated 12-dodecanolides as emerald ash borer pheromone mimetics

A series of five 12-dodecanolides have been synthesised containing CF2 groups at C5, C6, C7, C8 and in one case, a double substitution at C5 & C8, as a strategy to bias the conformational space accessed by these macrocycles, and to assess if th