(R)-2,3-Dihydroxy-3-methyl-butyric acid benzyl ester

Base Information

Chemical Name:(R)-2,3-Dihydroxy-3-methyl-butyric acid benzyl ester
CAS No.:184528-76-5
Molecular Formula:C12H16O4
Molecular Weight:224.257
Hs Code.:
DSSTox Substance ID:DTXSID70449280
Nikkaji Number:J773.828E
Mol file:184528-76-5.mol

Synonyms:184528-76-5;(R)-2,3-DIHYDROXY-3-METHYL-BUTYRIC ACID BENZYL ESTER;benzyl (2r)-2,3-dihydroxy-3-methylbutanoate;(R)-Benzyl 2,3-dihydroxy-3-methylbutanoate;Benzyl (R)-2,3-dihydroxy-3-methylbutanoate;SCHEMBL2036355;DTXSID70449280;HUYOGRCHSFVCNV-JTQLQIEISA-N;Butanoic acid, 2,3-dihydroxy-3-methyl-, phenylmethyl ester, (2R)-;MFCD29086947;BS-41951;(R)-Benzyl2,3-dihydroxy-3-methylbutanoate;CS-0038946;W11806;(R)-2,3-Dihydroxy-3-methylbutanoic acid benzyl ester

Suppliers and Price of (R)-2,3-Dihydroxy-3-methyl-butyric acid benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of (R)-2,3-Dihydroxy-3-methyl-butyric acid benzyl ester

Chemical Property:

XLogP3:0.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:224.10485899
Heavy Atom Count:16
Complexity:231

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C(C(=O)OCC1=CC=CC=C1)O)O
Isomeric SMILES:CC(C)([C@H](C(=O)OCC1=CC=CC=C1)O)O

Technology Process of (R)-2,3-Dihydroxy-3-methyl-butyric acid benzyl ester

There total 5 articles about (R)-2,3-Dihydroxy-3-methyl-butyric acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 37526-89-9
benzyl 3-methylbut-2-enoate

: 184528-76-5
(R)-benzyl 2,3-dihydroxy-3-methylbutanoate

Guidance literature:: With AD-mix-α; methanesulfonamide; sodium hydrogencarbonate; sodium sulfite; In water; tert-butyl alcohol; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/ol8018852

Reference yield: 4.0%

: 37526-89-9
benzyl 3-methylbut-2-enoate

: 184528-76-5
(R)-benzyl 2,3-dihydroxy-3-methylbutanoate

: 100-51-6,185532-71-2
benzyl alcohol

Guidance literature:: With AD-mix-α; methanesulfonamide; sodium hydrogencarbonate; In water; tert-butyl alcohol; at 0 ℃; for 60h;

Reference yield:

: 541-47-9
3-Methylbutenoic acid

: 184528-76-5
(R)-benzyl 2,3-dihydroxy-3-methylbutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / n-Bu₄NBr, aq. KOH / CHCl₃ / 18 h / Heating

2: 80 percent / AD-mix-α, methanesulfonamide, NaHCO3 / H2O; 2-methyl-propan-2-ol / 60 h / 0 °C

With potassium hydroxide; AD-mix-α; methanesulfonamide; tetrabutylammomium bromide; sodium hydrogencarbonate; In chloroform; water; tert-butyl alcohol;