3,3'-Biindole

Base Information

• Chemical Name: 3,3'-Biindole
• CAS No.: 13637-37-1
• Molecular Formula: C16H12N2
• Molecular Weight: 232.285
• Hs Code.: 2933990090
• NSC Number: 137883
• DSSTox Substance ID: DTXSID30300621
• Nikkaji Number: J387.710H
• Wikidata: Q82043835
• Metabolomics Workbench ID: 101910
• Mol file: 13637-37-1.mol

Synonyms:1H,1'H-(3,3')biindolyl

Chemical Property of 3,3'-Biindole

Chemical Property:

• Boiling Point: 526.6°Cat760mmHg
• Flash Point: 247.8°C
• PSA: 31.58000
• Density: 1.293g/cm³
• LogP: 4.31620
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 1
• Exact Mass: 232.100048391
• Heavy Atom Count: 18
• Complexity: 274

Purity/Quality:

98%min ^*data from raw suppliers

1H,1''H-3,3''-Biindole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(=CN2)C3=CNC4=CC=CC=C43

Technology Process of 3,3'-Biindole

There total 33 articles about 3,3'-Biindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2,2'-(buta-1,3-diene-2,3-diyl)bis(nitrobenzene) (1421850-69-2) → 1H,1'H-[3,3']biindolyl (13637-37-1)

Guidance literature:

With 1,10-Phenanthroline; carbon monoxide; 1,3-bis-(diphenylphosphino)propane; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 120 ℃; for 36h; under 4560.31 Torr;

DOI:10.1021/acs.joc.6b01987

Reference yield: 79.0%

3-[2-nitro-1-(2-nitrophenyl)ethyl]-1H-indole (1046140-09-3,1046140-86-6) → 1H,1'H-[3,3']biindolyl (13637-37-1)

Guidance literature:

With iron; acetic acid; for 2.5h; Reflux;

DOI:10.1002/ejoc.201000276

Reference yield: 74.0%

3-hydroxy-3-indolyl-2-oxindole (33333-60-7) → 1H,1'H-[3,3']biindolyl (13637-37-1)

Guidance literature:

With sodium tetrahydroborate; boron trifluoride diethyl etherate; In 1,2-dimethoxyethane; water; at 20 ℃; for 1.5h;

upstream raw materials:

indole

3-bromoindole

(E)-1-nitro-2-(2-nitrovinyl)benzene

3,3-bis(3-indolyl)indoline

Downstream raw materials:

4-bromo-2-[3-(1H-indol-3-yl)-1H-indol-2-ylmethyl]phenol

5,10-dihydro[1,2,3,4]tetrathiocino[5,6-b:8,7-b']diindole

2-phenylsulfanyl-1H,1'H-3,3'-biindolyl

1,1'-bis(dimethylaminomethyl)-2,2'-bis-diphenylphosphino<3,3'>-biindolyl