N,N'-Bis(4-fluorophenyl)formamidine

Base Information

• Chemical Name: N,N'-Bis(4-fluorophenyl)formamidine
• CAS No.: 18464-36-3
• Molecular Formula: C₁₃H₁₀F₂N₂
• Molecular Weight: 232.233
• European Community (EC) Number: 662-236-6
• Nikkaji Number: J928.364A
• Mol file: 18464-36-3.mol

Synonyms:N,N'-Bis(4-fluorophenyl)formamidine;AKOS024339831

Chemical Property of N,N'-Bis(4-fluorophenyl)formamidine

Chemical Property:

• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 232.08120465
• Heavy Atom Count: 17
• Complexity: 242

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=CC=C1NC=NC2=CC=C(C=C2)F)F

Technology Process of N,N'-Bis(4-fluorophenyl)formamidine

There total 6 articles about N,N'-Bis(4-fluorophenyl)formamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

formamide (77287-34-4,77287-35-5,60100-09-6) + 4-fluoroaniline (371-40-4) → N,N’-bis(4-fluorophenyl)formamidine (141417-89-2,18464-36-3)

Guidance literature:

With phosphorus tribromide; at 50 - 60 ℃; Inert atmosphere;

DOI:10.1021/jo301463m

Reference yield: 95.0%

orthoformic acid triethyl ester (122-51-0) + 4-fluoroaniline (371-40-4) → N,N’-bis(4-fluorophenyl)formamidine (141417-89-2,18464-36-3)

Guidance literature:

orthoformic acid triethyl ester; at 20 ℃; for 0.25h;

4-fluoroaniline; at 70 ℃; for 8h;

DOI:10.1016/j.molstruc.2012.06.009

Reference yield: 56.0%

→ N,N’-bis(4-fluorophenyl)formamidine (141417-89-2,18464-36-3)

Guidance literature:

With iron(II) acetylacetonate; phenylsilane; tris(2-diphenylphosphinoethyl)phosphine; In tetrahydrofuran; at 100 ℃; for 24h; Inert atmosphere; Glovebox; Schlenk technique;

upstream raw materials:

N,N-dimethyl-formamide

orthoformic acid triethyl ester

4-fluoroaniline

formamide

Downstream raw materials:

4-Cyan-3-(4-fluor-phenylamino)-benzo<4,5>thieno<2,3-c>pyridin-9,9-dioxid

2-(4-Fluor-anilinomethylen)-2,3-dihydro-3-oxo-benzo-thiophen-1,1-dioxid

2-(4-Fluor-anilinomethylen)-2,3-dihydro-3-oxo-benzo-thiophen-1,1-dioxid

Re(CO)4CH(NC₆H₄F)2

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