Carbamic acid, [3-[2-(formylamino)-5-[[(methylamino)sulfonyl]methyl]phenyl]-3-oxopropyl ]methyl-, phenylmethyl ester

Base Information

• Chemical Name: Carbamic acid, [3-[2-(formylamino)-5-[[(methylamino)sulfonyl]methyl]phenyl]-3-oxopropyl ]methyl-, phenylmethyl ester
• CAS No.: 184646-61-5
• Molecular Formula: C21H25N3O6S
• Molecular Weight: 447.512
• Mol file: 184646-61-5.mol

Synonyms:

Chemical Property of Carbamic acid, [3-[2-(formylamino)-5-[[(methylamino)sulfonyl]methyl]phenyl]-3-oxopropyl ]methyl-, phenylmethyl ester

Chemical Property:

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [3-[2-(formylamino)-5-[[(methylamino)sulfonyl]methyl]phenyl]-3-oxopropyl ]methyl-, phenylmethyl ester

There total 2 articles about Carbamic acid, [3-[2-(formylamino)-5-[[(methylamino)sulfonyl]methyl]phenyl]-3-oxopropyl ]methyl-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

phenylmethyl methyl[2-[5-[[(methylamino)sulphonyl]methyl]-1H-indol-3-yl]ethyl]carbamate (103628-53-1) → [3-(2-formylamino-5-methylsulphamoylmethylphenyl)-3-oxopropyl]methylcarbamic acid benzyl ester (184646-61-5)

Guidance literature:

With ozone; In N,N-dimethyl-formamide; at -10 ℃; for 0.0833333h;

DOI:10.1002/(SICI)1099-1344(199611)38:11<1021::AID-JLCR921>3.0.CO;2-O

Reference yield:

N-methyl-2-[5-[[(methylamino)sulphonyl]methyl]-1H-indol-3-yl]ethanamine (88919-51-1) → [3-(2-formylamino-5-methylsulphamoylmethylphenyl)-3-oxopropyl]methylcarbamic acid benzyl ester (184646-61-5)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. Na₂CO₃ / tetrahydrofuran; propan-2-ol / 20 °C

2: 66 percent / O₃ / dimethylformamide / 0.08 h / -10 °C

With sodium carbonate; ozone; In tetrahydrofuran; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1002/(SICI)1099-1344(199611)38:11<1021::AID-JLCR921>3.0.CO;2-O

Reference yield:

[14C]potassium cyanide (5373-08-0) + [3-(2-formylamino-5-methylsulphamoylmethylphenyl)-3-oxopropyl]methylcarbamic acid benzyl ester (184646-61-5) → C20(14)CH26N4O5S

Guidance literature:

With water; In ethanol; at 20 ℃; for 4h;

DOI:10.1002/(SICI)1099-1344(199611)38:11<1021::AID-JLCR921>3.0.CO;2-O

upstream raw materials:

phenylmethyl methyl[2-[5-[[(methylamino)sulphonyl]methyl]-1H-indol-3-yl]ethyl]carbamate

N-methyl-2-[5-[[(methylamino)sulphonyl]methyl]-1H-indol-3-yl]ethanamine