damvar

Base Information

• Chemical Name: damvar
• CAS No.: 62782-57-4
• Molecular Formula: C₉H₁₃N₃O₄
• Molecular Weight: 227.22
• Hs Code.: 2933599090
• Mol file: 62782-57-4.mol

Synonyms:5-Pyrimidinepentanoicacid, 2-amino-1,4-dihydro-6-hydroxy-4-oxo- (9CI); 2-Amino-6-hydroxy-5-(4-carboxybutyl)-3,4-dihydro-4-oxopyrimidine;Damvar; VUFB 9777

Chemical Property of damvar

Chemical Property:

• PSA: 130.29000
• Density: 1.57g/cm³
• LogP: 0.19750

Purity/Quality:

5-(2-AMINO-4,6-DIHYDROXY-5-PYRIMIDINYL)PENTANOIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of damvar

There total 2 articles about damvar which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1,1,5-pentanetricarboxylic acid triethyl ester (53007-36-6) + guanidine hydrochloride (50-01-1) → 5-(2-amino-6-hydroxy-4-oxo-3,4-dihydro-5-pyrimidinyl)pentanoic acid (62782-57-4)

Guidance literature:

With sodium ethanolate; In ethanol; for 4h; Ambient temperature;

DOI:10.1135/cccc19803583

Reference yield: 66.0%

5-(2-amino-5-bromo-4,6-dioxo-1,4,5,6-tetrahydropyrimidine-5-yl)pentanoic acid (87043-83-2) → δ-(2-amino-6-hydroxy-3,4-dihydro-4-oxo-5-pyrimidinyl)-valeric acid (62782-57-4)

Guidance literature:

With sodium hydroxide; for 4h; Heating;

DOI:10.1135/cccc19831212

Reference yield:

δ-(2-amino-6-hydroxy-3,4-dihydro-4-oxo-5-pyrimidinyl)-valeric acid (62782-57-4) → Cyclohexyl amide of 5-(2-Amino-6-hydroxy-4-oxo-3,4-dihydro-5-pyrimidinyl)-pentanoic acid (94991-07-8)

Guidance literature:

Multi-step reaction with 3 steps

1: Thionyl chloride

2: 89 percent

3: 72 percent / 8 h / 100 - 110 °C

With thionyl chloride;

upstream raw materials:

1,1,5-pentanetricarboxylic acid triethyl ester

guanidine hydrochloride

5-(2-amino-5-bromo-4,6-dioxo-1,4,5,6-tetrahydropyrimidine-5-yl)pentanoic acid

Downstream raw materials:

Cyclohexyl amide of 5-(2-Amino-6-hydroxy-4-oxo-3,4-dihydro-5-pyrimidinyl)-pentanoic acid