Carbamic acid, [1,6-dihydro-2-methyl-6-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-2-oxo-1-(phenyl methyl)propyl]amino]ethyl]-5-pyrimidinyl]-, phenylmethyl ester

Base Information

Chemical Name:Carbamic acid, [1,6-dihydro-2-methyl-6-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-2-oxo-1-(phenyl methyl)propyl]amino]ethyl]-5-pyrimidinyl]-, phenylmethyl ester
CAS No.:184709-69-1
Molecular Formula:C25H23F3N4O5
Molecular Weight:516.477
Hs Code.:
Mol file:184709-69-1.mol

Carbamic acid,
[1,6-dihydro-2-methyl-6-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-2-oxo-1-(phenyl
methyl)propyl]amino]ethyl]-5-pyrimidinyl]-, phenylmethyl ester

Synonyms:

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Chemical Property of Carbamic acid, [1,6-dihydro-2-methyl-6-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-2-oxo-1-(phenyl methyl)propyl]amino]ethyl]-5-pyrimidinyl]-, phenylmethyl ester

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Technology Process of Carbamic acid, [1,6-dihydro-2-methyl-6-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-2-oxo-1-(phenyl methyl)propyl]amino]ethyl]-5-pyrimidinyl]-, phenylmethyl ester

There total 4 articles about Carbamic acid, [1,6-dihydro-2-methyl-6-oxo-1-[2-oxo-2-[[3,3,3-trifluoro-2-oxo-1-(phenyl methyl)propyl]amino]ethyl]-5-pyrimidinyl]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 184711-46-4
{1-[(1-benzyl-3,3,3-trifluoro-2-hydroxy-propylcarbamoyl)-methyl]-2-methyl-6-oxo-1,6-dihydro-pyrimidin-5-yl}-carbamic acid benzyl ester

: 184709-69-1
2-(5-benzyloxycarbonylamino-2-methyl-6-oxo-1,6-dihydro-1-pyrimidinyl)-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide

Guidance literature:: With dichloro-acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dimethyl sulfoxide; toluene; at 20 ℃;
DOI:10.1016/S0968-0896(00)00244-3

Reference yield:

: 124044-49-1
3-amino-1,1,1-trifluoro-4-phenyl-2-butanol

: 184709-69-1
2-(5-benzyloxycarbonylamino-2-methyl-6-oxo-1,6-dihydro-1-pyrimidinyl)-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: HOBT; EDC / dimethylformamide / 20 °C

2: EDC; Cl₂CHCO₂H / dimethylsulfoxide; toluene / 20 °C

With dichloro-acetic acid; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 1: condensation / 2: oxidation;
DOI:10.1016/S0968-0896(00)00244-3

Reference yield:

: 177742-29-9
(5-benzyloxycarbonylamino-2-methyl-6-oxo-1,6-dihydro-1-pyrimidinyl)acetic acid

: 184709-69-1
2-(5-benzyloxycarbonylamino-2-methyl-6-oxo-1,6-dihydro-1-pyrimidinyl)-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: HOBT; EDC / dimethylformamide / 20 °C

2: EDC; Cl₂CHCO₂H / dimethylsulfoxide; toluene / 20 °C

With dichloro-acetic acid; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 1: condensation / 2: oxidation;
DOI:10.1016/S0968-0896(00)00244-3