(5-benzyloxycarbonylamino-2-methyl-6-oxo-1,6-dihydro-1-pyrimidinyl)acetic acid

Base Information

Chemical Name:(5-benzyloxycarbonylamino-2-methyl-6-oxo-1,6-dihydro-1-pyrimidinyl)acetic acid
CAS No.:177742-29-9
Molecular Formula:C₁₅H₁₅N₃O₅
Molecular Weight:317.301
Hs Code.:

Synonyms:(5-benzyloxycarbonylamino-2-methyl-6-oxo-1,6-dihydro-1-pyrimidinyl)acetic acid

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Chemical Property of (5-benzyloxycarbonylamino-2-methyl-6-oxo-1,6-dihydro-1-pyrimidinyl)acetic acid

Chemical Property:

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Technology Process of (5-benzyloxycarbonylamino-2-methyl-6-oxo-1,6-dihydro-1-pyrimidinyl)acetic acid

There total 1 articles about (5-benzyloxycarbonylamino-2-methyl-6-oxo-1,6-dihydro-1-pyrimidinyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 177742-29-9
(5-benzyloxycarbonylamino-2-methyl-6-oxo-1,6-dihydro-1-pyrimidinyl)acetic acid

Guidance literature:

Reference yield:

: (S)-3-Amino-4-oxo-5-(2-phenyl-5-trifluoromethyl-2H-pyrazol-3-yloxy)-pentanoic acid tert-butyl ester; hydrochloride

: 177742-29-9
(5-benzyloxycarbonylamino-2-methyl-6-oxo-1,6-dihydro-1-pyrimidinyl)acetic acid

: (S)-3-[2-(5-Benzyloxycarbonylamino-2-methyl-6-oxo-6H-pyrimidin-1-yl)-acetylamino]-4-oxo-5-(2-phenyl-5-trifluoromethyl-2H-pyrazol-3-yloxy)-pentanoic acid tert-butyl ester

Guidance literature:: With 4-methyl-morpholine; chloroformic acid ethyl ester; In tetrahydrofuran; at 0 ℃; for 1h;
DOI:10.1021/jm9601516

Reference yield:

: 177742-29-9
(5-benzyloxycarbonylamino-2-methyl-6-oxo-1,6-dihydro-1-pyrimidinyl)acetic acid

: 2-(5-amino-2-methyl-6-oxo-1,6-dihydro-1-pyrimidyl)-N-(1-benzyl-3,3,3-trifluoro-2-oxopropyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: HOBT; EDC / dimethylformamide / 20 °C

2: EDC; Cl₂CHCO₂H / dimethylsulfoxide; toluene / 20 °C

3: 41 percent / formic acid / Pd/C / methanol / 22 h / 20 °C

With dichloro-acetic acid; formic acid; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 1: condensation / 2: oxidation / 3: deacylation;
DOI:10.1016/S0968-0896(00)00244-3