Methanone, (2-cyclohexyl-6-hydroxybenzo(b)thien-3-yl)(4-(2-(1-piperidinyl)ethoxy)phenyl)-

Base Information

Chemical Name:Methanone, (2-cyclohexyl-6-hydroxybenzo(b)thien-3-yl)(4-(2-(1-piperidinyl)ethoxy)phenyl)-
CAS No.:150797-71-0
Molecular Formula:C28H33 N O3 S
Molecular Weight:463.641
Hs Code.:
DSSTox Substance ID:DTXSID00164611
Wikidata:Q83033674
ChEMBL ID:CHEMBL47944
Mol file:150797-71-0.mol

Synonyms:(2-cyclohexy-6-hydroxybenzo(b)thien-3-yl)(4-(2-(1- piperidinyl)ethoxy)phenyl) methanone hydrochloride;TZE-5323

Suppliers and Price of Methanone, (2-cyclohexyl-6-hydroxybenzo(b)thien-3-yl)(4-(2-(1-piperidinyl)ethoxy)phenyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of Methanone, (2-cyclohexyl-6-hydroxybenzo(b)thien-3-yl)(4-(2-(1-piperidinyl)ethoxy)phenyl)-

Chemical Property:

XLogP3:7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:463.21811509
Heavy Atom Count:33
Complexity:625

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCC(CC1)C2=C(C3=C(S2)C=C(C=C3)O)C(=O)C4=CC=C(C=C4)OCCN5CCCCC5

Technology Process of Methanone, (2-cyclohexyl-6-hydroxybenzo(b)thien-3-yl)(4-(2-(1-piperidinyl)ethoxy)phenyl)-

There total 6 articles about Methanone, (2-cyclohexyl-6-hydroxybenzo(b)thien-3-yl)(4-(2-(1-piperidinyl)ethoxy)phenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 150797-34-5
(6-Methoxy-2-cyclohexylbenzo[b]thien-3-yl)[4-[2-(1-piperidinyl)ethoxy]phenyl]methanone

: 150797-71-0
(6-hydroxy-2-cyclohexylbenzo[b]thien-3-yl)-[4-[2-(1-piperidinyl)ethoxy]phenyl]methanone

Guidance literature:: With aluminium trichloride; 1-thiopropane; In 1,2-dichloro-ethane; at 5 - 20 ℃; for 5h;
DOI:10.1021/jm9606352

Reference yield:

: 931-50-0
cyclohexylmagnesium bromide

: 150797-71-0
(6-hydroxy-2-cyclohexylbenzo[b]thien-3-yl)-[4-[2-(1-piperidinyl)ethoxy]phenyl]methanone

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / tetrahydrofuran

2: 76 percent / EtSH, AlCl₃ / CH₂Cl₂

With aluminium trichloride; ethanethiol; In tetrahydrofuran; dichloromethane;
DOI:10.1016/0960-894X(95)00575-E

Reference yield:

: 165742-76-7
[2-dimethylamino-6-methoxybenzothien-3-yl] [4-[2-(1-piperidinyl)ethoxy]phenyl]-methanone

: 150797-71-0
(6-hydroxy-2-cyclohexylbenzo[b]thien-3-yl)-[4-[2-(1-piperidinyl)ethoxy]phenyl]methanone

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / tetrahydrofuran

2: 76 percent / EtSH, AlCl₃ / CH₂Cl₂

With aluminium trichloride; ethanethiol; In tetrahydrofuran; dichloromethane;
DOI:10.1016/0960-894X(95)00575-E