1H-Imidazole-5-carboxylic acid, 2-butyl-4-(methylthio)-1-[[2'-[[[(propylamino)thioxomethyl]amino]sulfonyl][ 1,1'-biphenyl]-4-yl]methyl]-, ethyl ester

Base Information

Chemical Name:1H-Imidazole-5-carboxylic acid, 2-butyl-4-(methylthio)-1-[[2'-[[[(propylamino)thioxomethyl]amino]sulfonyl][ 1,1'-biphenyl]-4-yl]methyl]-, ethyl ester
CAS No.:184881-74-1
Molecular Formula:C28H36N4O4S3
Molecular Weight:588.816
Hs Code.:
Mol file:184881-74-1.mol

1H-Imidazole-5-carboxylic acid,
2-butyl-4-(methylthio)-1-[[2'-[[[(propylamino)thioxomethyl]amino]sulfonyl][
1,1'-biphenyl]-4-yl]methyl]-, ethyl ester

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Imidazole-5-carboxylic acid, 2-butyl-4-(methylthio)-1-[[2'-[[[(propylamino)thioxomethyl]amino]sulfonyl][ 1,1'-biphenyl]-4-yl]methyl]-, ethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 1H-Imidazole-5-carboxylic acid, 2-butyl-4-(methylthio)-1-[[2'-[[[(propylamino)thioxomethyl]amino]sulfonyl][ 1,1'-biphenyl]-4-yl]methyl]-, ethyl ester

There total 12 articles about 1H-Imidazole-5-carboxylic acid, 2-butyl-4-(methylthio)-1-[[2'-[[[(propylamino)thioxomethyl]amino]sulfonyl][ 1,1'-biphenyl]-4-yl]methyl]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 628-30-8
n-Propyl isothiocyanate

: 144629-51-6
ethyl 1-<<2'-(aminosulfonyl)(1,1'-biphenyl)-4-yl>methyl>-2-butyl-4-(methylthio)-1H-imidazole-5-carboxylate

: 184881-74-1
ethyl 2-butyl-4-(methylthio)-1-<<2'-<<<(propylamino)thioxomethyl>amino>sulfonyl>(1,1-biphenyl)-4-yl>methyl>-1H-imidazole-5-carboxylate

Guidance literature:: With potassium carbonate; In acetone; for 15h; Heating;
DOI:10.1021/jm00013a013 DOI:10.1080/00397919608003832

Reference yield:

: 5720-05-8
4-methylphenylboronic acid

: 184881-74-1
ethyl 2-butyl-4-(methylthio)-1-<<2'-<<<(propylamino)thioxomethyl>amino>sulfonyl>(1,1-biphenyl)-4-yl>methyl>-1H-imidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / aq. Na₂CO₃, triphenylphosphine, palladium acetate / ethanol; toluene / 4 h / Heating

2: 64 percent / N-bromosuccinimide, benzoyl peroxide / chlorobenzene / 1 h / 120 °C

3: K₂CO₃ / dimethylformamide / 45 h / 20 - 25 °C

4: 81 percent / conc. HCl / ethanol / 2 h / Heating

5: 86 percent / K₂CO₃ / acetone / 15 h / Heating

With hydrogenchloride; N-Bromosuccinimide; Perbenzoic acid; palladium diacetate; sodium carbonate; potassium carbonate; triphenylphosphine; In ethanol; N,N-dimethyl-formamide; chlorobenzene; acetone; toluene;
DOI:10.1021/jm00013a013

Reference yield:

: 92748-09-9
2-bromobenzene-1-sulfonamide

: 184881-74-1
ethyl 2-butyl-4-(methylthio)-1-<<2'-<<<(propylamino)thioxomethyl>amino>sulfonyl>(1,1-biphenyl)-4-yl>methyl>-1H-imidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / dimethylformamide / 2 h / Ambient temperature

2: 93 percent / aq. Na₂CO₃, triphenylphosphine, palladium acetate / ethanol; toluene / 4 h / Heating

3: 64 percent / N-bromosuccinimide, benzoyl peroxide / chlorobenzene / 1 h / 120 °C

4: K₂CO₃ / dimethylformamide / 45 h / 20 - 25 °C

5: 81 percent / conc. HCl / ethanol / 2 h / Heating

6: 86 percent / K₂CO₃ / acetone / 15 h / Heating

With hydrogenchloride; N-Bromosuccinimide; Perbenzoic acid; palladium diacetate; sodium carbonate; potassium carbonate; triphenylphosphine; In ethanol; N,N-dimethyl-formamide; chlorobenzene; acetone; toluene;
DOI:10.1021/jm00013a013