1H-Imidazole-5-carboxylic acid, 2-butyl-4-(methylthio)-1-[[2'-[[[(propylamino)carbonyl]amino]sulfonyl][1,1' -biphenyl]-4-yl]methyl]-, ethyl ester

Base Information

• Chemical Name: 1H-Imidazole-5-carboxylic acid, 2-butyl-4-(methylthio)-1-[[2'-[[[(propylamino)carbonyl]amino]sulfonyl][1,1' -biphenyl]-4-yl]methyl]-, ethyl ester
• CAS No.: 144628-51-3
• Molecular Formula: C28H36N4O5S2
• Molecular Weight: 572.75

Synonyms:

Chemical Property of 1H-Imidazole-5-carboxylic acid, 2-butyl-4-(methylthio)-1-[[2'-[[[(propylamino)carbonyl]amino]sulfonyl][1,1' -biphenyl]-4-yl]methyl]-, ethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 1H-Imidazole-5-carboxylic acid, 2-butyl-4-(methylthio)-1-[[2'-[[[(propylamino)carbonyl]amino]sulfonyl][1,1' -biphenyl]-4-yl]methyl]-, ethyl ester

There total 24 articles about 1H-Imidazole-5-carboxylic acid, 2-butyl-4-(methylthio)-1-[[2'-[[[(propylamino)carbonyl]amino]sulfonyl][1,1' -biphenyl]-4-yl]methyl]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

Propyl isocyanate (110-78-1) + ethyl 1-<<2'-(aminosulfonyl)(1,1'-biphenyl)-4-yl>methyl>-2-butyl-4-(methylthio)-1H-imidazole-5-carboxylate (144629-51-6) → ethyl 2-butyl-4-(methylthio)-1-[[2'-[[[(propylamino)-carbonyl]-amino]-sulfonyl]-(1,1'-biphenyl)-4-yl]-methyl]-1H-imidazole-5-carboxylate (144628-51-3)

Guidance literature:

With potassium carbonate; In acetone; for 2h; Heating;

DOI:10.1021/jm00013a013

Reference yield: 76.0%

ethyl 3-amino-2-[[[2'-[[[(propylamino)-carbonyl]-amino]sulfonyl]-(1,1'-biphenyl)-4-yl]-methyl]-(1-oxopentyl)-amino]-3-(methylthio)-2-propenoate (184287-40-9) → ethyl 2-butyl-4-(methylthio)-1-[[2'-[[[(propylamino)-carbonyl]-amino]-sulfonyl]-(1,1'-biphenyl)-4-yl]-methyl]-1H-imidazole-5-carboxylate (144628-51-3)

Guidance literature:

With sulfuric acid; In 1,2-dimethoxyethane; for 1h; Ambient temperature;

DOI:10.1055/s-1996-4383

Reference yield: 60.0%

ethyl 2-butyl-4-(methylthio)-1-<<2'-<<<(propylamino)thioxomethyl>amino>sulfonyl>(1,1-biphenyl)-4-yl>methyl>-1H-imidazole-5-carboxylate (184881-74-1) → ethyl 2-butyl-4-(methylthio)-1-[[2'-[[[(propylamino)-carbonyl]-amino]-sulfonyl]-(1,1'-biphenyl)-4-yl]-methyl]-1H-imidazole-5-carboxylate (144628-51-3)

Guidance literature:

With water; mercury(II) oxide; In ethanol; at 55 ℃;

DOI:10.1080/00397919608003832

upstream raw materials:

Propyl isocyanate

ethyl 1-<<2'-(aminosulfonyl)(1,1'-biphenyl)-4-yl>methyl>-2-butyl-4-(methylthio)-1H-imidazole-5-carboxylate

ethyl 3-amino-2-[[[2'-[[[(propylamino)-carbonyl]-amino]sulfonyl]-(1,1'-biphenyl)-4-yl]-methyl]-(1-oxopentyl)-amino]-3-(methylthio)-2-propenoate

ethyl 2-butyl-4-(methylthio)-1-<<2'-<<<(propylamino)thioxomethyl>amino>sulfonyl>(1,1-biphenyl)-4-yl>methyl>-1H-imidazole-5-carboxylate

Downstream raw materials:

N-[(2-butyl-4-(methylthio)-1-{[2'-({[(propylamino)carbonyl]amino}sulfonyl)(1,1'-biphenyl)-4-yl]methyl}-1H-imidazol-5-yl)carbonyl]glycine methyl ester

C₂₆H₃₁ClN₄O₄S₂

2-butyl-4-(methylthio)-1-[[2'-((((propylamino)-carbonyl)-amino)-sulfonyl)-(1,1'-biphenyl)-4-yl]-methyl]-1H-imidazole-5-carboxylic acid

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