23-O-Demycinosyltylosin

Base Information

Chemical Name:23-O-Demycinosyltylosin
CAS No.:79592-92-0
Molecular Formula:C38H63NO13
Molecular Weight:741.9057
Hs Code.:
ChEMBL ID:CHEMBL296337
Wikidata:Q105384488

Synonyms:23-O-Demycinosyltylosin;23-O-Desmycinosyl-tylosin;CHEMBL296337;79592-92-0;HY-N11421;CS-0646267

Suppliers and Price of 23-O-Demycinosyltylosin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
23-O-Desmycinosyl-tylosin
5mg
$ 460.00

TRC
23-O-Desmycinosyl-tylosin
5mg
$ 165.00

American Custom Chemicals Corporation
23-DEMYCINOSYLTYLOSIN 95.00%
5MG
$ 496.22

Total 5 raw suppliers

Chemical Property of 23-O-Demycinosyltylosin

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:890.7°Cat760mmHg
Flash Point:492.5°C
PSA：201.75000
Density:1.23g/cm³
LogP:1.67350
XLogP3:1
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:9
Exact Mass:741.42994106
Heavy Atom Count:52
Complexity:1240

Purity/Quality:

≥85.0% ^*data from raw suppliers

23-O-Desmycinosyl-tylosin ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC1C(C=C(C=CC(=O)C(CC(C(C(C(CC(=O)O1)O)C)OC2C(C(C(C(O2)C)OC3CC(C(C(O3)C)O)(C)O)N(C)C)O)CC=O)C)C)CO
Isomeric SMILES:CC[C@@H]1[C@H](/C=C(/C=C/C(=O)[C@@H](C[C@@H]([C@@H]([C@H]([C@@H](CC(=O)O1)O)C)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)C)O[C@H]3C[C@@]([C@H]([C@@H](O3)C)O)(C)O)N(C)C)O)CC=O)C)\C)CO
Uses 23-O-Desmycinosyl-tylosin is used in the synthesis of tylosin-related macrolides modified at the aldehyde functional group. These compounds act as orally effective antibiotics. Also, a degredation product of tylosin macromolecules.

Technology Process of 23-O-Demycinosyltylosin

There total 17 articles about 23-O-Demycinosyltylosin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3067-23-0
4-O-acetylmycarose

: 79592-92-0
23-demycinosyltylosin

Guidance literature:: Multi-step reaction with 5 steps

1: TsCl / acetonitrile; triethylamine / 4 h / 20 °C

2: 17 percent / 1,3-dibromo-5,5-dimethylhydantoin / acetonitrile; toluene / 5 h / -30 - 20 °C

3: 82 percent / 90percent CF₃COOH / 1 h / 5 °C

4: 90 percent / Bu3SnH / α,α'-azobisisobutyronitrile / benzene; toluene / 5 h / 45 °C

5: 1.) MeOH; 2.) K₂CO₃ / 1.) 40 deg C, 6 h; 2.) MeOH, 20 deg C, 4 h

With methanol; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; tri-n-butyl-tin hydride; potassium carbonate; p-toluenesulfonyl chloride; trifluoroacetic acid; azobisisobutyronitrile; In triethylamine; toluene; acetonitrile; benzene;
DOI:10.1016/S0040-4039(00)87619-4

Reference yield:

: 84171-64-2
4-O-acetyl-1,5-anhydro-2,6-dideoxy-3-C-methyl-L-ribo-hex-1-enitol

: 79592-92-0
23-demycinosyltylosin

Guidance literature:: Multi-step reaction with 4 steps

1: 17 percent / 1,3-dibromo-5,5-dimethylhydantoin / acetonitrile; toluene / 5 h / -30 - 20 °C

2: 82 percent / 90percent CF₃COOH / 1 h / 5 °C

3: 90 percent / Bu3SnH / α,α'-azobisisobutyronitrile / benzene; toluene / 5 h / 45 °C

4: 1.) MeOH; 2.) K₂CO₃ / 1.) 40 deg C, 6 h; 2.) MeOH, 20 deg C, 4 h

With methanol; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; tri-n-butyl-tin hydride; potassium carbonate; trifluoroacetic acid; azobisisobutyronitrile; In toluene; acetonitrile; benzene;
DOI:10.1016/S0040-4039(00)87619-4

Reference yield:

: 51548-96-0,68510-46-3,112937-15-2,112937-16-3
1-α-bromo-2,4-diacetyl-mycaminose hydrobromide

: 79592-92-0
23-demycinosyltylosin

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) HgO, HgBr₂ / 1.) dioxane, Drierite, 20 deg C, 17 h; 2.) 40 deg C, 24 h

2: 60 percent / acetonitrile / 0.5 h / 5 °C

3: 17 percent / 1,3-dibromo-5,5-dimethylhydantoin / acetonitrile; toluene / 5 h / -30 - 20 °C

4: 82 percent / 90percent CF₃COOH / 1 h / 5 °C

5: 90 percent / Bu3SnH / α,α'-azobisisobutyronitrile / benzene; toluene / 5 h / 45 °C

6: 1.) MeOH; 2.) K₂CO₃ / 1.) 40 deg C, 6 h; 2.) MeOH, 20 deg C, 4 h

With methanol; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; tri-n-butyl-tin hydride; potassium carbonate; trifluoroacetic acid; mercury dibromide; mercury(II) oxide; azobisisobutyronitrile; In toluene; acetonitrile; benzene;
DOI:10.1016/S0040-4039(00)87619-4