DIETHYL 2-[(2,5-DIFLUOROANILINO)METHYLENE]MALONATE

Base Information

Chemical Name:DIETHYL 2-[(2,5-DIFLUOROANILINO)METHYLENE]MALONATE
CAS No.:185010-73-5
Molecular Formula:C14H15F2NO4
Molecular Weight:299.274
Hs Code.:
Mol file:185010-73-5.mol

Synonyms:diethyl 2-((2,5-difluorophenylamino)methylene)maIonate;diethyl 2-((2,5-difluorophenylamino)methylene)malonate;2-[(2,5-Difluoro-phenylamino)-methylene]-malonic acid diethyl ester;

Suppliers and Price of DIETHYL 2-[(2,5-DIFLUOROANILINO)METHYLENE]MALONATE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
DIETHYL-2-[(2,5-DIFLUOROANILINO)METHYLENE]MALONATE 95.00%
5MG
$ 687.35

American Custom Chemicals Corporation
DIETHYL-2-[(2,5-DIFLUOROANILINO)METHYLENE]MALONATE 95.00%
10MG
$ 679.14

American Custom Chemicals Corporation
DIETHYL-2-[(2,5-DIFLUOROANILINO)METHYLENE]MALONATE 95.00%
1MG
$ 647.61

Total 0 raw suppliers

Chemical Property of DIETHYL 2-[(2,5-DIFLUOROANILINO)METHYLENE]MALONATE

Chemical Property:

Melting Point:88 °C (hexane)
PSA：64.63000
LogP:2.45980

Purity/Quality:: DIETHYL-2-[(2,5-DIFLUOROANILINO)METHYLENE]MALONATE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of DIETHYL 2-[(2,5-DIFLUOROANILINO)METHYLENE]MALONATE

There total 1 articles about DIETHYL 2-[(2,5-DIFLUOROANILINO)METHYLENE]MALONATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 367-30-6
2,5-difluoroaniline

: 87-13-8
diethyl 2-ethoxymethylenemalonate

: 185010-73-5
diethyl 2-(((2,5-difluorophenyl)amino)methylene)malonate

Guidance literature:: at 100 - 120 ℃;
DOI:10.1021/jm400540b

Reference yield:

: 185010-73-5
diethyl 2-(((2,5-difluorophenyl)amino)methylene)malonate

: 1443361-95-2
5,8-difluoro-1-(4-methoxybenzyl)-N-(methylsulfonyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: Eaton's reagent / 90 - 100 °C / Inert atmosphere

2.1: potassium iodide; potassium carbonate / N,N-dimethyl-formamide / 20 °C

3.1: hydrogenchloride / 1,4-dioxane; water / 2 h / Reflux

4.1: dichloromethane / 3.5 h / 0 °C / Inert atmosphere

4.2: 1.02 h / 20 °C / Inert atmosphere; Cooling with ice

5.1: dichloromethane / 0 °C / Inert atmosphere

5.2: 0 - 20 °C / Inert atmosphere

With hydrogenchloride; Eaton's reagent; potassium carbonate; potassium iodide; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm400540b

Reference yield:

: 185010-73-5
diethyl 2-(((2,5-difluorophenyl)amino)methylene)malonate

: 1443361-61-2
1-([1,1′-biphenyl]-4-ylmethyl)-8-fluoro-5-hydroxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: Eaton's reagent / 90 - 100 °C / Inert atmosphere

2.1: potassium iodide; potassium carbonate / N,N-dimethyl-formamide / 20 °C

3.1: water; sodium hydroxide / 1,4-dioxane / 3.5 h / 80 °C

3.2: Reflux

3.3: 1 h / 160 °C / Microwave irradiation; Sealed tube

With Eaton's reagent; water; potassium carbonate; potassium iodide; sodium hydroxide; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm400540b