5,8-Difluoro-4-hydroxyquinoline-3-carboxylic acid

Base Information

Chemical Name:5,8-Difluoro-4-hydroxyquinoline-3-carboxylic acid
CAS No.:223690-44-6
Molecular Formula:C₁₀H₅F₂NO₃
Molecular Weight:225.151
Hs Code.:2933499090
DSSTox Substance ID:DTXSID20595680
Nikkaji Number:J1.092.197J
Wikidata:Q82490747
Mol file:223690-44-6.mol

Synonyms:5,8-Difluoro-4-hydroxyquinoline-3-carboxylic acid;223690-44-6;5,8-Difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid;797052-45-0;5,8-difluoro-4-oxo-1H-quinoline-3-carboxylic acid;SCHEMBL6198912;DTXSID20595680;FQMPPOUNRNUMIQ-UHFFFAOYSA-N;MFCD03407972;AKOS005175370;SB69066;EN300-220643;F51187;5,8-difluoro-4-hydroxy-3-quinolinecarboxylic acid;5,8-Difluoro-4-hydroxyquinoline-3-carboxylicacid;F3374-0965;Z2442102751

Suppliers and Price of 5,8-Difluoro-4-hydroxyquinoline-3-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5,8-difluoro-4-hydroxyquinoline-3-carboxylicAcid
50mg
$ 130.00

American Custom Chemicals Corporation
5,8-DIFLUORO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID 95.00%
5MG
$ 498.31

AK Scientific
5,8-Difluoro-4-hydroxyquinoline-3-carboxylicacid
1g
$ 637.00

Total 2 raw suppliers

Chemical Property of 5,8-Difluoro-4-hydroxyquinoline-3-carboxylic acid

Chemical Property:

Vapor Pressure:8.84E-07mmHg at 25°C
Boiling Point:390°C at 760 mmHg
Flash Point:189.6°C
PSA：70.42000
Density:1.653g/cm³
LogP:1.91680
XLogP3:2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:1
Exact Mass:225.02374935
Heavy Atom Count:16
Complexity:369

Purity/Quality:

97% ^*data from raw suppliers

5,8-difluoro-4-hydroxyquinoline-3-carboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C2C(=C1F)C(=O)C(=CN2)C(=O)O)F

Technology Process of 5,8-Difluoro-4-hydroxyquinoline-3-carboxylic acid

There total 4 articles about 5,8-Difluoro-4-hydroxyquinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 185011-67-0,223690-43-5
ethyl 5,8-difluoro-4-hydroxy-3-quinolinecarboxylate

: 223690-44-6,797052-45-0
5,8-Difluoro-4-hydroxyquinoline-3-carboxylic acid

Guidance literature:: With sodium hydroxide; water; at 1 ℃; Heating;
DOI:10.1016/S0022-1139(98)00310-8

Reference yield:

aqueous lithium hydroxide: aqueous lithium hydroxide

: 185011-67-0,223690-43-5
ethyl 5,8-difluoro-4-hydroxy-3-quinolinecarboxylate

: 223690-44-6,797052-45-0
5,8-Difluoro-4-hydroxyquinoline-3-carboxylic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol; acetic acid;

Reference yield:

: 367-30-6
2,5-difluoroaniline

: 223690-44-6,797052-45-0
5,8-Difluoro-4-hydroxyquinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / 1.33 h / 100 °C

2: 65 percent / diphenyl ether / 1 h / 250 °C

3: 98 percent / NaOH; H₂O / 1 °C / Heating

With sodium hydroxide; water; In diphenylether; 1: Condensation / 2: Cyclization / 3: Hydrolysis;
DOI:10.1016/S0022-1139(98)00310-8