4-Ethylamino-2-phenylamino-pyrimidine-5-carboxylic acid ethyl ester

Base Information

Chemical Name:4-Ethylamino-2-phenylamino-pyrimidine-5-carboxylic acid ethyl ester
CAS No.:185040-37-3
Molecular Formula:C15H18N4O2
Molecular Weight:286.334
Hs Code.:
DSSTox Substance ID:DTXSID601186493
Mol file:185040-37-3.mol

Synonyms:SCHEMBL4714679;JCTZRCYKNANLNQ-UHFFFAOYSA-N;DTXSID601186493;185040-37-3;Ethyl 4-(ethylamino)-2-(phenylamino)-5-pyrimidinecarboxylate;4-Ethylamino-2-phenylamino-pyrimidine-5-carboxylic acid ethyl ester

Suppliers and Price of 4-Ethylamino-2-phenylamino-pyrimidine-5-carboxylic acid ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Ethylamino-2-phenylamino-pyrimidine-5-carboxylic acid ethyl ester

Chemical Property:

XLogP3:3.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:286.14297583
Heavy Atom Count:21
Complexity:321

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCNC1=NC(=NC=C1C(=O)OCC)NC2=CC=CC=C2

Technology Process of 4-Ethylamino-2-phenylamino-pyrimidine-5-carboxylic acid ethyl ester

There total 4 articles about 4-Ethylamino-2-phenylamino-pyrimidine-5-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 185040-36-2
4-ethylamino-2-methanesulfinyl-pyrimidine-5-carboxylic acid ethyl ester

: 185040-37-3
4-ethylamino-2-phenylamino-pyrimidine-5-carboxylic acid ethyl ester

Guidance literature:: In hexane; ethyl acetate; aniline;

Reference yield:

: 5909-24-0
4-chloro-2-methanesulfanylpyrimidine-5-carboxylic acid ethyl ester

: 185040-37-3
4-ethylamino-2-phenylamino-pyrimidine-5-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / Et₃N / tetrahydrofuran; H₂O / 0.5 h

2: 97 percent / (+/-)-trans-2-phenylsulfonyl-3-phenyloxaziridine / CHCl₃ / 7 h / Ambient temperature

3: 1 h / 130 °C

With N-(benzenesulfonyl)-3-phenyloxaziridine; triethylamine; In tetrahydrofuran; chloroform; water;
DOI:10.1021/jm980398y

Reference yield:

: 185040-33-9
4-ethylamino-2-methylsulfanyl-pyrimidine-5-carboxylic acid ethyl ester

: 185040-37-3
4-ethylamino-2-phenylamino-pyrimidine-5-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / (+/-)-trans-2-phenylsulfonyl-3-phenyloxaziridine / CHCl₃ / 7 h / Ambient temperature

2: 1 h / 130 °C

With N-(benzenesulfonyl)-3-phenyloxaziridine; In chloroform;
DOI:10.1021/jm980398y