2-Pyridinecarboxylic acid, 4-[1-[(acetyloxy)methyl]-1-hydroxypropyl]-6-methoxy-5-[(phenylmethoxy) methyl]-, propyl ester, (R)-

Base Information

Chemical Name:2-Pyridinecarboxylic acid, 4-[1-[(acetyloxy)methyl]-1-hydroxypropyl]-6-methoxy-5-[(phenylmethoxy) methyl]-, propyl ester, (R)-
CAS No.:185135-84-6
Molecular Formula:C24H31NO7
Molecular Weight:445.513
Hs Code.:
Mol file:185135-84-6.mol

Synonyms:

Suppliers and Price of 2-Pyridinecarboxylic acid, 4-[1-[(acetyloxy)methyl]-1-hydroxypropyl]-6-methoxy-5-[(phenylmethoxy) methyl]-, propyl ester, (R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 2-Pyridinecarboxylic acid, 4-[1-[(acetyloxy)methyl]-1-hydroxypropyl]-6-methoxy-5-[(phenylmethoxy) methyl]-, propyl ester, (R)-

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-Pyridinecarboxylic acid, 4-[1-[(acetyloxy)methyl]-1-hydroxypropyl]-6-methoxy-5-[(phenylmethoxy) methyl]-, propyl ester, (R)-

There total 12 articles about 2-Pyridinecarboxylic acid, 4-[1-[(acetyloxy)methyl]-1-hydroxypropyl]-6-methoxy-5-[(phenylmethoxy) methyl]-, propyl ester, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 108-22-5
Isopropenyl acetate

: 183433-74-1
5-Benzyloxymethyl-4-(1-hydroxy-1-hydroxymethyl-propyl)-6-methoxy-pyridine-2-carboxylic acid propyl ester

: 183433-75-2
5-Benzyloxymethyl-4-((S)-1-hydroxy-1-hydroxymethyl-propyl)-6-methoxy-pyridine-2-carboxylic acid propyl ester

: 185135-84-6
4-((R)-1-Acetoxymethyl-1-hydroxy-propyl)-5-benzyloxymethyl-6-methoxy-pyridine-2-carboxylic acid propyl ester

Guidance literature:: With PS-30 catalyst; In various solvent(s); for 48h;
DOI:10.1021/jo970173f

Reference yield:

: 5398-44-7
2,6-dichloropyridine-4-carboxylic acid

: 185135-84-6
4-((R)-1-Acetoxymethyl-1-hydroxy-propyl)-5-benzyloxymethyl-6-methoxy-pyridine-2-carboxylic acid propyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 84 percent / tetrahydrofuran / 1 h / 0 °C

2: 100 percent / TMSCl / 12 h / Ambient temperature

3: 89 percent / methanol / 20 h / Heating

4: 1.) n-BuLi / 1.) heptane, hexane, 0 deg C, 30 min, 2.) hexane, heptane, -30 deg C - 0 deg C, 1 h

5: 71 percent / NaBH₄, n-Bu₄NCl / H₂O / 18 h

6: 99.3 percent / t-BuOK / tetrahydrofuran / 1 h / 20 - 30 °C

7: 89 percent / Pd(OAc)2, K₂CO₃, DPP / dimethylformamide / 16 h / 90 °C / 775.7 Torr

9: 92 percent / OsO₄, Me₃NO*2H₂O / 2-methyl-propan-2-ol / 24 h / 40 °C

10: 60 percent / PS-30 catalyst / various solvent(s) / 48 h

With palladium diacetate; sodium tetrahydroborate; osmium(VIII) oxide; n-butyllithium; chloro-trimethyl-silane; trimethylamine-N-oxide; PS-30 catalyst; parathion; potassium tert-butylate; tetrabutyl-ammonium chloride; potassium carbonate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jo970173f

Reference yield:

: 99-11-6
citrazinic acid

: 185135-84-6
4-((R)-1-Acetoxymethyl-1-hydroxy-propyl)-5-benzyloxymethyl-6-methoxy-pyridine-2-carboxylic acid propyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: 78 percent / POPCl₃, Me₄NCl / 2 h / 130 - 142 °C

2: 84 percent / tetrahydrofuran / 1 h / 0 °C

3: 100 percent / TMSCl / 12 h / Ambient temperature

4: 89 percent / methanol / 20 h / Heating

5: 1.) n-BuLi / 1.) heptane, hexane, 0 deg C, 30 min, 2.) hexane, heptane, -30 deg C - 0 deg C, 1 h

6: 71 percent / NaBH₄, n-Bu₄NCl / H₂O / 18 h

7: 99.3 percent / t-BuOK / tetrahydrofuran / 1 h / 20 - 30 °C

8: 89 percent / Pd(OAc)2, K₂CO₃, DPP / dimethylformamide / 16 h / 90 °C / 775.7 Torr

10: 92 percent / OsO₄, Me₃NO*2H₂O / 2-methyl-propan-2-ol / 24 h / 40 °C

11: 60 percent / PS-30 catalyst / various solvent(s) / 48 h

With palladium diacetate; sodium tetrahydroborate; osmium(VIII) oxide; n-butyllithium; chloro-trimethyl-silane; trimethylamine-N-oxide; POPCl₃; PS-30 catalyst; parathion; potassium tert-butylate; tetrabutyl-ammonium chloride; tetramethlyammonium chloride; potassium carbonate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jo970173f