189684-08-0Relevant academic research and scientific papers
Diversity oriented synthesis of natural 2-arylbenzofuran, moracin F
Yun, So-Ra,Jun, Jong-Gab
, p. 1253 - 1258 (2016)
Diversity oriented synthesis of natural 2-arylbenzofuran, moracin F (1) has been carried out from the commercially available starting materials using Sonogashira coupling, Suzuki coupling, neutral Al2O3 mediated cyclization, and intr
CHEMICAL COMPOUNDS FOR COATING OF NANOSTRUCTURES
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Page/Page column 43; 44, (2018/08/03)
The present application relates to a chemical compound comprising an aromatic core, or a carbocyclic, non-aromatic, core, wherein the aromatic core is a benzene ring or a biphenyl; the carbocyclic, non-aromatic core is a 5 to 7 membered ring. The core has
Mixing End Groups in Thiol-Ene/Yne Reactions as a Simple Approach toward Multienzyme-Responsive Polymeric Amphiphiles
Harnoy, Assaf J.,Papo, Nitsan,Slor, Gadi,Amir, Roey J.
supporting information, p. 2582 - 2587 (2018/11/30)
Taking advantage of the high fidelity of thiol-ene and thiol-yne chemistries, we used mixtures of thiols to prepare degradable PEG-dendron amphiphiles functionalized with two different types of enzymatically cleavable end groups. By tuning the feed ratios of the two thiols, we achieved mixtures of hybrids with statistically different ratios of end groups. Studies of the disassembly of statistically mixed hybrids showed that these amphiphiles have higher degrees of response when incubated with each of the activating enzymes, whereas a greater degree of selectivity was observed for a control mixture of two distinct amphiphiles, which required the presence of both types of enzyme to undergo complete disassembly. The potential to introduce different end groups by using a mixture of thiols in an efficient single thiol-ene or thiol-yne step opens the way for simple modification of various ene- or yne-containing polymers and tailoring of their structural and functional properties.
Synthesizing method of piceatannol 3'-O-belta-D-glucopyranoside
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Paragraph 0114-0118, (2017/10/13)
The invention belongs to the field of synthesizing of compounds, and particularly relates to a synthesizing method of piceatannol 3'-O-belta-D-glucopyranoside. The synthesizing method is characterized in that a compound in a formula VIII is reacted, so as to obtain the piceatannol 3'-O-belta-D-glucopyranoside shown in a formula I, wherein in the formula VIII, R is acetyl, benzyl, allyl or alloc. The synthesizing method has the advantages that the compound of piceatannol 3'-O-belta-D-glucopyranoside is synthesized; the cost of the used reagent is low, and the obtaining is easy; the operation is simple, and the total yield rate is 26%; a simple, efficient and environment-friendly piceatannol 3'-O-belta-D-glucopyranoside synthesizing route is provided, a first path is opened for the chemical synthesizing of the piceatannol 3'-O-belta-D-glucopyranoside, and the important meaning is realized in the field of medicines. The formula I and the formula VIII are shown in the description.
Synthetic method for moracin F using Sonogashira coupling reaction
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Paragraph 0072-0073, (2017/10/20)
The present invention relates to a method for synthesizing a natural compound, moracin F having biological activity. The synthesis method of the present invention can efficiently synthesize the moracin F having biological activity by using Sonogashira cou
Synthetic method for moracin F using intramolecular Wittig reaction
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Paragraph 0065; 0066, (2017/10/31)
The present invention provides a method for synthesizing a natural compound moracin F having biological activity. When using the method of the present invention, moracin F having a biological activity can be effectively synthesized by using an intramolecu
Synthetic method for moracin F using Suzuki coupling reaction
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Paragraph 0038; 0073; 0074, (2017/11/09)
An objective of the present invention is to provide a method for synthesizing a natural compound moracin F having biological activity. Inventors of the present invention can efficiently synthesize moracin F having biological activity by using Suzuki coupl
Inhibitors of the FEZ-1 metallo-β-lactamase
Lienard, Benoit M.R.,Horsfall, Louise E.,Galleni, Moreno,Frere, Jean-Marie,Schofield, Christopher J.
, p. 964 - 968 (2008/12/23)
Metallo-β-lactamases (MBLs) catalyze the hydrolysis of β-lactams including penicillins, cephalosporins and carbapenems. Starting from benzohydroxamic acid (1) structure-activity studies led to the identification of selective inhibitors of the FEZ-1 MBL, e.g., 2,5-substituted benzophenone hydroxamic acid 17 has a Ki of 6.1 ± 0.7 μM against the FEZ-1 MBL but does not significantly inhibit the IMP-1, BcII, CphA or L1 MBLs.
Contrast media
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, (2008/06/13)
The invention provides low viscosity iodinated aryl compounds, useful as X-ray contrast agents of formula I wherein n is 0 or 1, and where n is 1 each C6R5moiety may be the same or different; X denotes a bond or a group providing a 1
Iodinated x-ray contrast media
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, (2008/06/13)
The invention provides low viscosity iodinated aryl compounds, useful as X-ray contrast agents, of formula C6R6wherein three non-adjacent R groups are iodine and the remaining R groups are non-ionic, hydrophilic moieties, said compou
