Bis-propargyl-PEG6

Base Information

• Chemical Name: Bis-propargyl-PEG6
• CAS No.: 185378-83-0
• Molecular Formula: C16H26O6
• Molecular Weight: 314.37400
• Mol file: 185378-83-0.mol

Synonyms:4,7,10,13,16,19-hexaoxodocosa-1,21-diyne;3-[2-(2-{2-[2-(2-Prop-2-ynyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-propyne;bis-O-propargyl-penta(ethylene glycol);

Chemical Property of Bis-propargyl-PEG6

Chemical Property:

• Melting Point: 36 - 37 °C
• PSA: 55.38000
• LogP: 0.35240
• Solubility.: Soluble in DMSO, DCM, DMF

Purity/Quality:

98%,99%, ^*data from raw suppliers

Bis-propargyl-PEG6 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Bis-propargyl-PEG6 has two propargyl groups which can participate in Click Chemistry reactions to yield a stable triazole linkage with azide compounds; copper is needed as a catalyst. The 6 units of PEG increase the hydrophilicity of the compound.

Technology Process of Bis-propargyl-PEG6

There total 1 articles about Bis-propargyl-PEG6 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

Pentaethylene glycol (4792-15-8) + propargyl bromide (106-96-7) → 4,7,10,13,16,19-hexaoxodocosa-1,21-diyne (185378-83-0)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; 0 deg C, 1h; rt, 14 h;

DOI:10.1021/jo961583r

Reference yield: 100.0%

tri-O-benzyl-α-L-fucopyranosyl-(1->4)-2-acetamido-3,6-di-O-benzoyl-2-deoxy-β-D-glucopyranosyl azide (953780-99-9) + 4,7,10,13,16,19-hexaoxodocosa-1,21-diyne (185378-83-0) → C114H126N8O28

Guidance literature:

copper(l) iodide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;

DOI:10.1039/b708227d

Reference yield: 55.0%

N-(3-azidopropyl)-2,3,4,6-tetra-O-benzyl-1,5-dideoxy-1,5-imino-D-glucitol (1119249-25-0) + 4,7,10,13,16,19-hexaoxodocosa-1,21-diyne (185378-83-0) → bis-1,18-[1-(3-(2,3,4,6-tetra-O-benzyl-1,5-dideoxy-1,5-imino-D-glucitol-N-yl)-propyl)triazol-4-yl]-2,5,8,11,14,17-hexaoxaoctadecane (1119249-29-4)

Guidance literature:

With copper(II) sulfate; sodium L-ascorbate; In 1,4-dioxane; water; at 80 ℃; for 0.5h; Microwave irradiation;

DOI:10.1039/b815408b

upstream raw materials:

Pentaethylene glycol

propargyl bromide

Downstream raw materials:

bis-1,18-[1-(3-(2,3,4,6-tetra-O-benzyl-1,5-dideoxy-1,5-imino-D-glucitol-N-yl)-propyl)triazol-4-yl]-2,5,8,11,14,17-hexaoxaoctadecane