(6-Methoxy-2-phenylbenzo[b]thien-3-yl)[4-[2-(1-piperidinyl)ethoxy]phenyl]methanone

Base Information

Chemical Name:(6-Methoxy-2-phenylbenzo[b]thien-3-yl)[4-[2-(1-piperidinyl)ethoxy]phenyl]methanone
CAS No.:185416-18-6
Molecular Formula:C29H29NO3S
Molecular Weight:471.62
Hs Code.:
DSSTox Substance ID:DTXSID101131693
ChEMBL ID:CHEMBL44792
Mol file:185416-18-6.mol

Synonyms:CHEMBL44792;SCHEMBL8598366;DTXSID101131693;BDBM50471404;(6-Methoxy-2-phenylbenzo[b]thien-3-yl)[4-[2-(1-piperidinyl)ethoxy]phenyl]methanone;185416-18-6

Suppliers and Price of (6-Methoxy-2-phenylbenzo[b]thien-3-yl)[4-[2-(1-piperidinyl)ethoxy]phenyl]methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of (6-Methoxy-2-phenylbenzo[b]thien-3-yl)[4-[2-(1-piperidinyl)ethoxy]phenyl]methanone

Chemical Property:

XLogP3:6.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:471.18681496
Heavy Atom Count:34
Complexity:639

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC2=C(C=C1)C(=C(S2)C3=CC=CC=C3)C(=O)C4=CC=C(C=C4)OCCN5CCCCC5

Technology Process of (6-Methoxy-2-phenylbenzo[b]thien-3-yl)[4-[2-(1-piperidinyl)ethoxy]phenyl]methanone

There total 3 articles about (6-Methoxy-2-phenylbenzo[b]thien-3-yl)[4-[2-(1-piperidinyl)ethoxy]phenyl]methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 100-58-3
phenylmagnesium bromide

: 165742-76-7
[2-dimethylamino-6-methoxybenzothien-3-yl] [4-[2-(1-piperidinyl)ethoxy]phenyl]-methanone

: 185416-18-6
(6-Methoxy-2-phenyl-benzo[b]thiophen-3-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone

Guidance literature:: In tetrahydrofuran; for 1.5h; Ambient temperature;
DOI:10.1021/jm9606352

Reference yield:

: 111359-29-6
6-methoxy-N,N-dimethylbenzo[b]thiophen-2-amine

: 185416-18-6
(6-Methoxy-2-phenyl-benzo[b]thiophen-3-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone

Guidance literature:: Multi-step reaction with 2 steps

1: 64 percent / chlorobenzene / 9 h / 100 - 105 °C

2: 87 percent / tetrahydrofuran / 1.5 h / Ambient temperature

In tetrahydrofuran; chlorobenzene;
DOI:10.1021/jm9606352

Reference yield:

: 4-[2-(piperidin-1-yl)ethoxy]benzoyl chloride hydrochloride

: 185416-18-6
(6-Methoxy-2-phenyl-benzo[b]thiophen-3-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone

Guidance literature:: Multi-step reaction with 2 steps

1: 64 percent / chlorobenzene / 9 h / 100 - 105 °C

2: 87 percent / tetrahydrofuran / 1.5 h / Ambient temperature

In tetrahydrofuran; chlorobenzene;
DOI:10.1021/jm9606352