D-Phenylalanine, N-[3-[[(1,1-dimethylethoxy)carbonyl]amino]propyl]-

Base Information

Chemical Name:D-Phenylalanine, N-[3-[[(1,1-dimethylethoxy)carbonyl]amino]propyl]-
CAS No.:185426-25-9
Molecular Formula:C17H26N2O4
Molecular Weight:322.404
Hs Code.:
Mol file:185426-25-9.mol

Synonyms:

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Chemical Property of D-Phenylalanine, N-[3-[[(1,1-dimethylethoxy)carbonyl]amino]propyl]-

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Technology Process of D-Phenylalanine, N-[3-[[(1,1-dimethylethoxy)carbonyl]amino]propyl]-

There total 5 articles about D-Phenylalanine, N-[3-[[(1,1-dimethylethoxy)carbonyl]amino]propyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.5%

: 174799-62-3
(R)-2-[Benzyl-(3-tert-butoxycarbonylamino-propyl)-amino]-3-phenyl-propionic acid

: 185426-25-9
(R)-2-(3-tert-Butoxycarbonylamino-propylamino)-3-phenyl-propionic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; for 4h; under 2585.7 Torr; Ambient temperature;
DOI:10.1021/jo961580e

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 185426-25-9
(R)-2-(3-tert-Butoxycarbonylamino-propylamino)-3-phenyl-propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / CHCl₃ / 1.) 3 h, ice bath, 2.) room temperature, 16 h

2: 1.) Et₃N, MgSO₄, 2.) NaBH₄ / 1.) MeOH, room temperature, 1.5 h, 2.) MeOH, -5 deg C (1.5 h), 0 deg C (1 h)

3: 51.5 percent / Et₃N / CH₂Cl₂ / 1.) 0 deg C, 30 min, 2.) room temperature, 18 h

4: 100 percent / 7.5 N NaOH / methanol / 24 h / Ambient temperature

5: 75.5 percent / H₂ / Pd/C / methanol; dimethylformamide / 4 h / 2585.7 Torr / Ambient temperature

With sodium hydroxide; sodium tetrahydroborate; hydrogen; magnesium sulfate; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jo961580e

Reference yield:

: 75178-96-0
N-Boc-1,3-diaminopropane

: 185426-25-9
(R)-2-(3-tert-Butoxycarbonylamino-propylamino)-3-phenyl-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Et₃N, MgSO₄, 2.) NaBH₄ / 1.) MeOH, room temperature, 1.5 h, 2.) MeOH, -5 deg C (1.5 h), 0 deg C (1 h)

2: 51.5 percent / Et₃N / CH₂Cl₂ / 1.) 0 deg C, 30 min, 2.) room temperature, 18 h

3: 100 percent / 7.5 N NaOH / methanol / 24 h / Ambient temperature

4: 75.5 percent / H₂ / Pd/C / methanol; dimethylformamide / 4 h / 2585.7 Torr / Ambient temperature

With sodium hydroxide; sodium tetrahydroborate; hydrogen; magnesium sulfate; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo961580e