75178-96-0

Basic information

• Product Name: N-Boc-1,3-propanediamine
• Synonyms: TERT-BUTYL N-(3-AMINOPROPYL)CARBAMATE;RARECHEM AR PA 0022;N-(TERT-BUTOXYCARBONYL)-1,3-DIAMINOPROPANE;N-(TERT-BUTOXYCARBONYL)-1,3-PROPANEDIAMINE;N-BOC-1,3-DIAMINOPROPANE;N-BOC-1,3-PROPANEDIAMINE;MONO-N-(T-BOC)-PROPYLENEDIAMINE;N-(3-AMINOPROPYL)CARBAMIC ACID TERT-BUTYL ESTER
• CAS NO: 75178-96-0
• Molecular Formula: C₈H₁₈N₂O₂
• Molecular Weight: 174.24
• EINECS: 1312995-182-4
• Product Categories: N-BOC;Amines and Anilines;pharmacetical;Monoprotected Diaminoalkanes;N-Boc-diaminoalkanes;Bifunctional Linkers;Building Blocks;Chemical Biology;Chemical Synthesis;Linkers and Crosslinkers;Nitrogen Compounds;Organic Building Blocks;Protected Amines
• Mol File: 75178-96-0.mol
• Article Data: 8

Chemical Properties

• Melting Point: 22 °C(lit.)
• Boiling Point: 203 °C(lit.)
• Flash Point: >230 °F
• Appearance: Colorless/Liquid
• Density: 0.998 g/mL at 20 °C(lit.)
• Vapor Pressure: 0.00633mmHg at 25°C
• Refractive Index: n20/D 1.454(lit.)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility: Miscible with methanol.
• PKA: 12.73±0.46(Predicted)
• Sensitive: Air Sensitive
• BRN: 3588328
• CAS DataBase Reference: N-Boc-1,3-propanediamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Boc-1,3-propanediamine(75178-96-0)
• EPA Substance Registry System: N-Boc-1,3-propanediamine(75178-96-0)

Safety Data

• Hazard Codes: C
• Statements: 22-34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3259 8/PG 3
• WGK Germany: 3
• F: 10-34
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 75178-96-0(Hazardous Substances Data)

Usage

Chemical Properties

Colorless to light yellow liquid

Uses

Different sources of media describe the Uses of 75178-96-0 differently. You can refer to the following data:
1. N-Boc-1,3-diaminopropane is used in the preparation of spermidine analogues as well as in the preparation of pharmacologically active compounds. It is also used in suzuki reaction. Further, it is used in the preparation of [3-(3-cyano-propylamino)-propyl]-carbamic acid tert-butyl ester.
2. suzuki reaction

InChI:InChI=1/C8H18N2O2/c1-8(2,3)12-7(11)10-6-4-5-9/h4-6,9H2,1-3H3,(H,10,11)/p+1

Upstream product

• 636794-26-8 3-Fluoro-4-(4-fluoro-benzyloxy)-benzoic Acid 
• 58885-58-8 N-tert-butoxycarbonyl-3-aminopropanol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 109-76-2 Trimethylenediamine 

Downstream Products

• 259222-01-0 N-[(3-(N-tert-butoxycarbonylamino)propyl)]acridine-9-carboxamide 
• 209616-26-2 2-benzyloxycarbonylamino-3-[6-(3-tert-butoxycarbonylamino-propylamino)-purin-9-yl]-propionic acid tert-butyl ester 
• 294625-11-9 N-[3-(tert-butoxycarbonyl)aminopropyl]-2(R)-[2-(carbobenzoxy)aminoacetylamino]-4-methylpentanamide 
• 476312-66-0 [3-(3-bromo-3-phenyl-propionylamino)-propyl]-carbamic acid tert-butyl ester 
• 575434-16-1 methyl 4-(3-tert-butoxycarbonylaminopropylsulfamoyl)-3-nitrobenzoate 
• 161038-07-9 N-(t-butyloxycarbonyl)-N'-(pepstatinyl)propane-1,3-diamine 
• 820224-71-3 t-butyl 3-[[5-chloro-4-[(4-chlorophenylthio)-(2,5-difluorophenyl)methyl]pyridin-2-yl]amino]propylcarbamate 
• 220470-20-2 [3-(4-cyanobenzoylamino)propyl]carbamic acid tert-butyl ester 
• 164979-16-2 N,N'-bis(N-tert.butoxycarbonyl-3-amino propyl)-4-(6-phenylhexyloxy)-1,3-benzenedimethanamine 
• 187530-16-1 p-methoxybenzyl [3-(t-butyloxycarbonylamino)-1-propylamino]acetate 
• 913358-64-2 C₃₆H₄₆ClN₅O₅ 
• 1085940-97-1 {3-[1-(3-Benzyl-4-oxo-3,4-dihydro-benzo[g]pteridin-2-yl)-2-methyl-propylamino]-propyl}-carbamic acid tert-butyl ester 
• 1085941-03-2 {3-[1-(3-benzyl-4-oxo-3,4-dihydro-pyrimido[4,5-b]quinolin-2-yl)-propylamino]-propyl}-carbamic acid tert-butyl ester 
• 1085940-90-4 {3-[1-(3-benzyl-4-oxo-3,4-dihydro-benzo[g]quinazolin-2-yl)-2-methyl-propylamino]-propyl}-carbamic acid tert-butyl ester 

Relevant articles and documents

Flow-mediated synthesis of Boc, Fmoc, and Dd iv monoprotected diamines

A series of monoprotected aliphatic diamines (21 examples) were synthesized via continuous flow methods. The carbamates and enamines were obtained in 45-91% yields using a 0.5 mm diameter PTFE tubular flow reactor. Using readily accessible protecting group precursors, the procedure serves as an attractive alternative to existing batch-mode synthetic routes by providing direct, multigram access to N-Boc-, N-Fmoc-, and N-Ddiv-protected compounds with productivity indexes of 1.2-3.6 g/h.

Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in Plasmodium falciparum and HL-60 cancer cell lines

A series of artemisinin-spermidine conjugates designed to utilise the upregulated polyamine transporter found in cancer cells have been prepared. These conjugates were evaluated against human promyelocytic leukaemia HL-60 cells and chloroquine-sensitive 3

Fluorobenzamides and uses thereof

The invention relates to fluorobenzamide derivatives of the formula wherein R1, R2, R3 R4, R5, R6 and R7 are as defined herein. =, The compounds of the invention are selective monoamine oxidase B inhibitors and therefore they are suitable for the treatment of diseases mediated by monoamine oxidase B, such as Alzheimer's disease or senile dementia.