Carbamic acid, [3-cyclohexyl-1-[(2,3-dihydrospiro[1H-indene-1,4'-piperidin]-1'-yl)carbon yl]propyl]-, 1,1-dimethylethyl ester, (R)-

Base Information

• Chemical Name: Carbamic acid, [3-cyclohexyl-1-[(2,3-dihydrospiro[1H-indene-1,4'-piperidin]-1'-yl)carbon yl]propyl]-, 1,1-dimethylethyl ester, (R)-
• CAS No.: 185525-70-6
• Molecular Formula: C₂₈H₄₂N₂O₃
• Molecular Weight: 454.653
• Mol file: 185525-70-6.mol

Synonyms:

Chemical Property of Carbamic acid, [3-cyclohexyl-1-[(2,3-dihydrospiro[1H-indene-1,4'-piperidin]-1'-yl)carbon yl]propyl]-, 1,1-dimethylethyl ester, (R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Carbamic acid, [3-cyclohexyl-1-[(2,3-dihydrospiro[1H-indene-1,4'-piperidin]-1'-yl)carbon yl]propyl]-, 1,1-dimethylethyl ester, (R)-

There total 3 articles about Carbamic acid, [3-cyclohexyl-1-[(2,3-dihydrospiro[1H-indene-1,4'-piperidin]-1'-yl)carbon yl]propyl]-, 1,1-dimethylethyl ester, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-Boc spiroindane (148835-99-8) → [1(R)-[(2,3-dihydrospiro[1H-indene-1,4'-piperidin]-1'-yl)carbonyl]-3-cyclohexylpropyl]carbamic acid 1,1-dimethylethyl ester (185525-70-6)

Guidance literature:

Multi-step reaction with 2 steps

1: HCl / ethyl acetate

2: EDC, HOBt, Et₃N

With hydrogenchloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In ethyl acetate;

DOI:10.1016/S0960-894X(99)00183-3

Reference yield:

2,3-dihydrospiro[1H-indene-1,4'-piperidine] (428-38-6) + 2-tert-butoxycarbonylamino-4-cyclohexyl-butyric acid (154731-88-1) → [1(R)-[(2,3-dihydrospiro[1H-indene-1,4'-piperidin]-1'-yl)carbonyl]-3-cyclohexylpropyl]carbamic acid 1,1-dimethylethyl ester (185525-70-6)

Guidance literature:

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine;

DOI:10.1016/S0960-894X(99)00183-3

Reference yield:

→ [1(R)-[(2,3-dihydrospiro[1H-indene-1,4'-piperidin]-1'-yl)carbonyl]-3-cyclohexylpropyl]carbamic acid 1,1-dimethylethyl ester (185525-70-6)

Guidance literature:

upstream raw materials:

2,3-dihydrospiro[1H-indene-1,4'-piperidine]

2-tert-butoxycarbonylamino-4-cyclohexyl-butyric acid

N-Boc spiroindane