428-38-6

Basic information

• Product Name: 2,3-DIHYDROSPIRO[INDENE-1,4'-PIPERIDINE]
• Synonyms: 2,3-DIHYDROSPIRO[INDENE-1,4'-PIPERIDINE];2,3-dihydrospiro[indene-1,4'-piperidine](SALTDATA: FREE);2,3-Dihydrospiro[1H-indene-1,4'-piperidine];4-Spiroindane-piperidine;Spiro[1H-indene-1,4'-piperidine],2,3-dihydro-;EOS-62209
• CAS NO: 428-38-6
• Molecular Formula: C₁₃H₁₇N
• Molecular Weight: 187.28078
• Mol File: 428-38-6.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,3-DIHYDROSPIRO[INDENE-1,4'-PIPERIDINE](CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DIHYDROSPIRO[INDENE-1,4'-PIPERIDINE](428-38-6)
• EPA Substance Registry System: 2,3-DIHYDROSPIRO[INDENE-1,4'-PIPERIDINE](428-38-6)

Safety Data

• Hazardous Substances Data: 428-38-6(Hazardous Substances Data)

Usage

General Description

2,3-Dihydrospiro[indene-1,4'-piperidine] is a chemical compound that belongs to the spiro compound family. It is characterized by a unique spiro ring system, consisting of an indene ring fused to a piperidine ring. 2,3-DIHYDROSPIRO[INDENE-1,4'-PIPERIDINE] has potential pharmacological importance due to its diverse biological activities, such as antipsychotic, analgesic, and anti-inflammatory properties. It has been studied for its potential use in the treatment of various neurological and psychiatric disorders. Additionally, the spiro structure of 2,3-dihydrospiro[indene-1,4'-piperidine] makes it an interesting target for synthetic and medicinal chemistry research, as it offers opportunities for the development of novel drugs with improved therapeutic profiles.

Upstream product

• 137419-24-0 1'-(tert-butyloxycarbonyl)spiro<1H-indene-1,4'-piperidine> 
• 148835-99-8 N-Boc spiroindane 

Downstream Products

• 137730-66-6 1-(2-phenyl-ethyl)-spiro[piperidine-4,1'-indane] 
• 185525-88-6 N-[1(R)-[(2,3-dihydrospiro[1H-indene-1,4'-piperidin]-1'-yl)carbonyl]-2-(phenylmethyloxy)ethyl]carbamic acid 1,1-dimethylethyl ester 
• 185525-70-6 [1(R)-[(2,3-dihydrospiro[1H-indene-1,4'-piperidin]-1'-yl)carbonyl]-3-cyclohexylpropyl]carbamic acid 1,1-dimethylethyl ester 
• 932720-88-2 Boc (R)-spiro[1H-indene-1,4'-piperidine], 1'-[2-amino-1-oxo-3-(2,4-dichlorophenyl)propyl]-2,3-dihydro 
• 137730-52-0 1'-Benzyl-2,3-Dihydrospiro[indene-1,4'-piperidine] 
• 1292291-70-3 Ethyl (3S)-3-[4-[[4-(spiro[indane-1,4'-piperidine]-1'-ylmethyl)phenyl]methoxy]phenyl]hex-4-ynoate 
• 1292291-10-1 (4-(spiro[indene-1,4'-piperidin]-1'-ylmethyl)phenyl)methanol 
• 915104-46-0 N-(4-Chlorophenyl)-2,3-dihydro-1'H-spiro[indene-1 ,4'-piperidine]-1'-carbothioamide 
• 137730-54-2 1'-cyclohexylmethylspiro[indane-1,4'-piperidine] 
• 574740-19-5 2,3-Dihydro-1'-[2-ethoxycarbonyl-3-(2-nitrophenyl)propyl]spiro[1H-indene-1,4'-piperidine] 

Relevant articles and documents

CARBOXYAMINE COMPOUNDS AND METHODS OF USE THEREOF

The invention relates to the use of carboxyamine compounds and salts thereof in the treatment of HDAC dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases.

Synthesis and biological activities of spiroheterocyclic growth hormone secretagogues

The synthesis and biological activities of a series of spiroheterocyclic growth hormone secretagogues are reported. Modification of the spiroindane part-structure of the prototypal secretagogue L-162,752 revealed that the spiroindane could be replaced with spirobenzodihydrothiophen derivatives to enhance not only in vitro potency but also oral activity. In this study non- aromatic D-2-amino-4-cyclohexylbutanoic analogs (8a-8d) were also identified to be active secretagogues.