428-38-6

Usage

Uses

Used in Pharmaceutical Industry:
2,3-DIHYDROSPIRO[INDENE-1,4'-PIPERIDINE] is used as a pharmaceutical agent for its potential role in the treatment of neurological and psychiatric disorders. Its antipsychotic, analgesic, and anti-inflammatory properties make it a promising candidate for further research and development in this field.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 2,3-DIHYDROSPIRO[INDENE-1,4'-PIPERIDINE] is utilized as a subject of study for its unique spiro ring system. Researchers are interested in exploring its structure for the development of novel drugs with improved therapeutic profiles, leveraging its diverse biological activities for innovative pharmaceutical applications.

Upstream product

• 137419-24-0 1'-(tert-butyloxycarbonyl)spiro<1H-indene-1,4'-piperidine> 
• 148835-99-8 N-Boc spiroindane 

Downstream Products

• 137730-52-0 1'-Benzyl-2,3-Dihydrospiro[indene-1,4'-piperidine] 
• 137730-55-3 C₂₁H₂₅NO 
• 137730-66-6 1-(2-phenyl-ethyl)-spiro[piperidine-4,1'-indane] 
• 574740-19-5 2,3-Dihydro-1'-[2-ethoxycarbonyl-3-(2-nitrophenyl)propyl]spiro[1H-indene-1,4'-piperidine] 
• 932720-88-2 Boc (R)-spiro[1H-indene-1,4'-piperidine], 1'-[2-amino-1-oxo-3-(2,4-dichlorophenyl)propyl]-2,3-dihydro 
• 915104-46-0 N-(4-Chlorophenyl)-2,3-dihydro-1'H-spiro[indene-1 ,4'-piperidine]-1'-carbothioamide 
• 1292291-10-1 (4-(spiro[indene-1,4'-piperidin]-1'-ylmethyl)phenyl)methanol 
• 1292291-70-3 Ethyl (3S)-3-[4-[[4-(spiro[indane-1,4'-piperidine]-1'-ylmethyl)phenyl]methoxy]phenyl]hex-4-ynoate 
• 137730-54-2 1'-cyclohexylmethylspiro[indane-1,4'-piperidine] 

Relevant academic research and scientific papers

INDOL-3-YL-CARBONYL-SPIRO-PIPERIDINE DERIVATIVES AS V1A RECEPTOR ANTAGONISTS

The invention relates to indol-3-yl-carbonyl-spiro-piperidine derivatives which act as V1a receptor antagonists and which are represented by Formula I: wherein the spiro-piperidine head group A and the residues R1, R2 and R3 are as defined herein. The invention further relates to pharmaceutical compositions containing such compounds, methods for preparing the compounds and pharmaceutical compositions, and their use in the treatment of dysmenorrhea, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, obsessive compulsive disorder, anxious and depressive disorders.

CARBOXYAMINE COMPOUNDS AND METHODS OF USE THEREOF

The invention relates to the use of carboxyamine compounds and salts thereof in the treatment of HDAC dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases.

Synthesis and biological activities of spiroheterocyclic growth hormone secretagogues

The synthesis and biological activities of a series of spiroheterocyclic growth hormone secretagogues are reported. Modification of the spiroindane part-structure of the prototypal secretagogue L-162,752 revealed that the spiroindane could be replaced with spirobenzodihydrothiophen derivatives to enhance not only in vitro potency but also oral activity. In this study non- aromatic D-2-amino-4-cyclohexylbutanoic analogs (8a-8d) were also identified to be active secretagogues.

SPIROCYCLIC ANTIPSYCHOTIC AGENTS

A class of spirocyclic piperidine derivatives are selective ligands at sigma recognition sites and are therefore useful in the treatment and/or prevention of psychiatric disorders.