1,2,3,4-Tetrahydro-1-(2-fluorophenyl)-2-(3-(trifluoromethyl)phenyl)isoquinoline

Base Information

Chemical Name:1,2,3,4-Tetrahydro-1-(2-fluorophenyl)-2-(3-(trifluoromethyl)phenyl)isoquinoline
CAS No.:96719-45-8
Molecular Formula:C₂₂H₁₇F₄N
Molecular Weight:371.377
Hs Code.:
DSSTox Substance ID:DTXSID40914379

Synonyms:1,2,3,4-Tetrahydro-1-(2-fluorophenyl)-2-(3-(trifluoromethyl)phenyl)isoquinoline;96719-45-8;Isoquinoline, 1,2,3,4-tetrahydro-1-(2-fluorophenyl)-2-(3-(trifluoromethyl)phenyl)-;C22H17F4N;DTXSID40914379;C22-H17-F4-N;LS-85979;1-(2-Fluorophenyl)-2-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydroisoquinoline

Suppliers and Price of 1,2,3,4-Tetrahydro-1-(2-fluorophenyl)-2-(3-(trifluoromethyl)phenyl)isoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 1,2,3,4-Tetrahydro-1-(2-fluorophenyl)-2-(3-(trifluoromethyl)phenyl)isoquinoline

Chemical Property:

Vapor Pressure:4.89E-08mmHg at 25°C
Boiling Point:442.8°Cat760mmHg
Flash Point:221.6°C
Density:1.265g/cm³
XLogP3:6.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:371.12971219
Heavy Atom Count:27
Complexity:493

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(C(C2=CC=CC=C21)C3=CC=CC=C3F)C4=CC=CC(=C4)C(F)(F)F

Technology Process of 1,2,3,4-Tetrahydro-1-(2-fluorophenyl)-2-(3-(trifluoromethyl)phenyl)isoquinoline

There total 6 articles about 1,2,3,4-Tetrahydro-1-(2-fluorophenyl)-2-(3-(trifluoromethyl)phenyl)isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 96719-11-8
1-(2-Fluoro-phenyl)-2-(3-trifluoromethyl-phenyl)-3,4-dihydro-isoquinolinium; iodide

: 96719-45-8
1-(2-Fluoro-phenyl)-2-(3-trifluoromethyl-phenyl)-1,2,3,4-tetrahydro-isoquinoline

Guidance literature:: With sodium tetrahydroborate; In methanol; Yield given;

Reference yield:

: 103-82-2
phenylacetic acid

: 96719-45-8
1-(2-Fluoro-phenyl)-2-(3-trifluoromethyl-phenyl)-1,2,3,4-tetrahydro-isoquinoline

Guidance literature:: Multi-step reaction with 6 steps

1: SOCl₂ / benzene / Heating

2: diethyl ether / Ambient temperature

3: 85 percent / LAH / dioxane; diethyl ether

4: 1.) SOCl₂ / 1.) benzene, reflux, 2.) ether, r.t.

5: 1.) POCl₃, conc. HCl, 2.) KI / 1.) reflux, 2.) H₂O

6: NaBH₄ / methanol

With hydrogenchloride; sodium tetrahydroborate; lithium aluminium tetrahydride; thionyl chloride; potassium iodide; trichlorophosphate; In 1,4-dioxane; methanol; diethyl ether; benzene;

Reference yield:

: 1939-21-5
2-phenyl-N-(3-(trifluoromethyl)phenyl)acetamide

: 96719-45-8
1-(2-Fluoro-phenyl)-2-(3-trifluoromethyl-phenyl)-1,2,3,4-tetrahydro-isoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / LAH / dioxane; diethyl ether

2: 1.) SOCl₂ / 1.) benzene, reflux, 2.) ether, r.t.

3: 1.) POCl₃, conc. HCl, 2.) KI / 1.) reflux, 2.) H₂O

4: NaBH₄ / methanol

With hydrogenchloride; sodium tetrahydroborate; lithium aluminium tetrahydride; thionyl chloride; potassium iodide; trichlorophosphate; In 1,4-dioxane; methanol; diethyl ether;