3,5-Bis(aMinoMethyl)benzoic acid dihydrochloride

Base Information

• Chemical Name: 3,5-Bis(aMinoMethyl)benzoic acid dihydrochloride
• CAS No.: 185963-32-0
• Molecular Formula: C9H12N2O2.2ClH
• Molecular Weight: 253.12600
• Mol file: 185963-32-0.mol

Synonyms:

Chemical Property of 3,5-Bis(aMinoMethyl)benzoic acid dihydrochloride

Chemical Property:

• PSA: 89.34000
• LogP: 3.30680
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

3,5-Bis(aminomethyl)benzoicaciddihydrochloride 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-Bis(aMinoMethyl)benzoic acid dihydrochloride

There total 5 articles about 3,5-Bis(aMinoMethyl)benzoic acid dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methyl 3,5-bis((N-formylformamido)methyl)benzoate (185963-31-9) → 3,5-bis(aminomethyl)benzoic acid dihydrochloride (185963-32-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 2h; Heating;

DOI:10.1002/hlca.19960790719

Reference yield:

3,5-bis(azidomethyl)benzoic acid → 3,5-bis(aminomethyl)benzoic acid hydrochloride (185963-32-0)

Guidance literature:

With triphenylphosphine; In tetrahydrofuran; hydrogenchloride; water;

Reference yield:

3,5-dimethylbenzoic acid (499-06-9) → 3,5-bis(aminomethyl)benzoic acid dihydrochloride (185963-32-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 97 percent / conc. H₂SO₄ / 48 h / Heating

2: 84 percent / NBS, AIBN / methyl formate / 20 h / Heating; Irradiation

3: 75 percent / acetonitrile / 4 h / Heating

4: 98 percent / conc. aq. HCl / dioxane / 2 h / Heating

With hydrogenchloride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sulfuric acid; In 1,4-dioxane; Methyl formate; acetonitrile;

DOI:10.1002/hlca.19960790719

upstream raw materials:

methyl 3,5-bis((N-formylformamido)methyl)benzoate

3,5-dimethylbenzoic acid

methyl 3,5-dimethylbenzoate

methyl 3,5-bis(bromomethyl)benzoate

Refernces

• 1、 -. "GLUCOSE-SENSITIVE ALBUMIN-BINDING DERIVATIVES". Page/Page column 47; 48; 49. . Retrieved 2019/05/30.
• 2、 -. "Amplifier molecules for enhancement of diagnosis and therapy". . . Retrieved 2008/06/13.