185963-31-9

Upstream product

• 29333-41-3 methyl 3,5-bis(bromomethyl)benzoate 
• 18197-26-7 sodium diformamide 
• 499-06-9 3,5-dimethylbenzoic acid 
• 25081-39-4 methyl 3,5-dimethylbenzoate 

Downstream Products

• 185963-32-0 3,5-bis(aminomethyl)benzoic acid dihydrochloride 
• 213740-68-2 3,5-Bis-(tert-butoxycarbonylamino-methyl)-benzoic acid methyl ester 
• 185963-33-1 3,5-bis(((tert-butoxycarbonyl)amino)methyl)benzoic acid 
• 185963-34-2 3,5-Bis-(tert-butoxycarbonylamino-methyl)-benzoic acid 2,5-dioxo-pyrrolidin-1-yl ester 
• 185963-35-3 11-[3,5-Bis-(tert-butoxycarbonylamino-methyl)-benzoylamino]-undecanoic acid 

Relevant academic research and scientific papers

GLUCOSE SENSITIVE INSULIN DERIVATIVES

The present invention relates to novel insulin derivatives and their use in the treatment or prevention of medical conditions relating to diabetes. The insulin derivatives are glucose sensitive and display glucose-sensitive albumin binding. The invention

GLUCOSE-SENSITIVE ALBUMIN-BINDING DERIVATIVES

This invention relates to glucose-sensitive albumin-binding diboron conjugates. More particularly the invention provides novel diboron compounds, and in particular diboronate or diboroxole compounds, useful as intermediate compounds for the synthesis of diboron conjugates. The diboron compounds are characterized by formula (I), which is: R1-X-R2, and wherein "X" is a mono- to multiatomic linker and where R1 and R2, which may be identical or different, each represents a group of Formula (lla) or (IIb) Also described are diboron conjugates represented by the general Formula (I'), which is: R1'-X'-R2', in which either the moeities R1' or R2' or X' carry a drug that is covalently attached to the diboron compound.

Tweezers with different bite: Increasing the affinity of synthetic receptors by varying the hinge part

With preservation of selectivity, the hinge part of tweezerlike synthetic receptor molecules can be varied to achieve a higher affinity. The synthetic peptidosulfonamide receptor (below left; R = Disperse Red 1) with the bis(aminomethyl)benzoic acid hinge selectively bound the tripeptide shown below on the right (K(a) = 4100 M-1). Combination of a diversity in the hinge part with that present in the tweezer arms will provide access to large and diverse synthetic receptor libraries.

164. Hydrolytical cleavage of TAR-RNA, the trans-Activation responsive region of HIV-1, by a bis(guanidinium) catalyst attached to arginine

Guanidinium compounds imitating the bis(arginine) structural motif of staphylococcal nuclease (e.g. 3) are known to be powerful catalysts for phosphoryl transfer reactions in dipolar aprotic solvents. Compound 3 also accelerates the hydrolysis of RNA (Hs