185963-31-9Relevant articles and documents
GLUCOSE SENSITIVE INSULIN DERIVATIVES
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, (2020/10/20)
The present invention relates to novel insulin derivatives and their use in the treatment or prevention of medical conditions relating to diabetes. The insulin derivatives are glucose sensitive and display glucose-sensitive albumin binding. The invention
Tweezers with different bite: Increasing the affinity of synthetic receptors by varying the hinge part
Loewik, Dennis W. P. M.,Weingarten, W. David,Broekema, Matthias,Brouwer, Arwin J.,Still, W. Clark,Liskamp, Rob M. J.
, p. 1846 - 1850 (2007/10/03)
With preservation of selectivity, the hinge part of tweezerlike synthetic receptor molecules can be varied to achieve a higher affinity. The synthetic peptidosulfonamide receptor (below left; R = Disperse Red 1) with the bis(aminomethyl)benzoic acid hinge selectively bound the tripeptide shown below on the right (K(a) = 4100 M-1). Combination of a diversity in the hinge part with that present in the tweezer arms will provide access to large and diverse synthetic receptor libraries.