Ethyl (2R)-2-(4-chlorophenoxy)propanoate

Base Information

Chemical Name:Ethyl (2R)-2-(4-chlorophenoxy)propanoate
CAS No.:18672-09-8
Molecular Formula:C11H13ClO3
Molecular Weight:228.675
Hs Code.:
DSSTox Substance ID:DTXSID70494811
Nikkaji Number:J2.524.173H
Wikidata:Q82342451

Synonyms:18672-09-8;SCHEMBL10022852;DTXSID70494811;Ethyl (2R)-2-(4-chlorophenoxy)propanoate

Suppliers and Price of Ethyl (2R)-2-(4-chlorophenoxy)propanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of Ethyl (2R)-2-(4-chlorophenoxy)propanoate

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:228.0553220
Heavy Atom Count:15
Complexity:200

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C(C)OC1=CC=C(C=C1)Cl
Isomeric SMILES:CCOC(=O)[C@@H](C)OC1=CC=C(C=C1)Cl

Technology Process of Ethyl (2R)-2-(4-chlorophenoxy)propanoate

There total 8 articles about Ethyl (2R)-2-(4-chlorophenoxy)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.7%

: 57057-80-4
ethyl (S)-2-[[(4-methylphenyl)sulfonyl]oxy]propanoate

: 106-48-9,82344-39-6
4-chloro-phenol

: 18672-09-8
(R)-(+)-ethyl 2-(p-chlorophenoxy)propionate

Guidance literature:: With potassium carbonate; at 104 ℃; for 0.2h; optical yield given as %ee; Microwave irradiation;
DOI:10.1080/00397910903395243

Reference yield: 83.0%

: 6111-99-5
ethyl diazoalaninate

: 106-48-9,82344-39-6
4-chloro-phenol

: 18672-09-8
(R)-(+)-ethyl 2-(p-chlorophenoxy)propionate

Guidance literature:: With 5A molecular sieve; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; copper(l) chloride; (S_a,S,S)-Ph-Spirobox; In dichloromethane; at 25 ℃; for 3h;
DOI:10.1021/ja074729k

Reference yield:

: 6111-99-5
ethyl diazoalaninate

: 106-48-9,82344-39-6
4-chloro-phenol

: 18672-09-8
(R)-(+)-ethyl 2-(p-chlorophenoxy)propionate

: 18672-08-7
(S)-(-)-ethyl 2-(4-chlorophenoxy)propionate

Guidance literature:: 4-chloro-phenol; With (Sp)-(-)-4,12-bis[4-isopropyl-3-(2-oxazolinyl)phenyl][2.2]paracyclophane; copper(II) bis(trifluoromethanesulfonate); sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; In dichloromethane; at 20 ℃; for 0.333333h; Molecular sieve; Inert atmosphere;

ethyl diazoalaninate; In dichloromethane; at 20 ℃; for 1h; Overall yield = 58 %; enantioselective reaction; Molecular sieve; Inert atmosphere;
DOI:10.1248/cpb.c18-00519