2H-Pyran-5-carboxylic acid, 3,4-dihydro-2,2-dimethyl-4-oxo-6-phenyl-, ethyl ester

Base Information

• Chemical Name: 2H-Pyran-5-carboxylic acid, 3,4-dihydro-2,2-dimethyl-4-oxo-6-phenyl-, ethyl ester
• CAS No.: 18782-63-3
• Molecular Formula: C16H18O4
• Molecular Weight: 274.317
• Mol file: 18782-63-3.mol

Synonyms:

Chemical Property of 2H-Pyran-5-carboxylic acid, 3,4-dihydro-2,2-dimethyl-4-oxo-6-phenyl-, ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2H-Pyran-5-carboxylic acid, 3,4-dihydro-2,2-dimethyl-4-oxo-6-phenyl-, ethyl ester

There total 2 articles about 2H-Pyran-5-carboxylic acid, 3,4-dihydro-2,2-dimethyl-4-oxo-6-phenyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3,3-Dimethylacryloyl chloride (3350-78-5) + ethyl 3-oxo-3-phenylpropionate (94-02-0) → Ethyl 3,4-dihydro-2,2-dimethyl-4-oxo-6-phenyl-2H-pyran-5-carboxylate (18782-63-3)

Guidance literature:

With triethylamine; calcium chloride; In dichloromethane; at 10 - 20 ℃; for 6h; Reagent/catalyst; Solvent;

DOI:10.1039/c4ra11174e

Reference yield:

1,3-Dichloro-3-methyl-2-butanone (57539-84-1) + ethyl 3-oxo-3-phenylpropionate (94-02-0) → Ethyl 3,4-dihydro-2,2-dimethyl-4-oxo-6-phenyl-2H-pyran-5-carboxylate (18782-63-3)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) THF, reflux for 2h, then cooled 2.) for 2h 0 deg C, then for 12h room temperature;

DOI:10.1016/S0040-4039(00)94935-9

Reference yield: 85.0%

Ethyl 3,4-dihydro-2,2-dimethyl-4-oxo-6-phenyl-2H-pyran-5-carboxylate (18782-63-3) → 6,6-dimethyl-4-phenyl-6,7-dihydro-3H-pyrano[4,3-c]isoxazol-3-one

Guidance literature:

With hydroxylamine hydrochloride; In ethanol; for 5h; Solvent; Reflux;

DOI:10.1016/j.ejmech.2016.09.020

upstream raw materials:

3,3-Dimethylacryloyl chloride

ethyl 3-oxo-3-phenylpropionate

1,3-Dichloro-3-methyl-2-butanone

Downstream raw materials:

Ethyl 6-benzoyl-3-hydroxy-5-methylbiphenyl-2-carboxylate