2-Methyl-2,3,4,5-tetrahydro-1h-2-benzazepine

Base Information

• Chemical Name: 2-Methyl-2,3,4,5-tetrahydro-1h-2-benzazepine
• CAS No.: 188570-15-2
• Molecular Formula: C11H15N
• DSSTox Substance ID: DTXSID70391316
• Nikkaji Number: J1.845.998A
• Wikidata: Q82188698

Synonyms:2-methyl-2,3,4,5-tetrahydro-1h-2-benzazepine;188570-15-2;SCHEMBL1950767;DTXSID70391316

Chemical Property of 2-Methyl-2,3,4,5-tetrahydro-1h-2-benzazepine

Chemical Property:

• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 161.120449483
• Heavy Atom Count: 12
• Complexity: 144

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCCC2=CC=CC=C2C1

Technology Process of 2-Methyl-2,3,4,5-tetrahydro-1h-2-benzazepine

There total 1 articles about 2-Methyl-2,3,4,5-tetrahydro-1h-2-benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

2-Methyl-2-trimethylsilanylmethyl-2,3,4,5-tetrahydro-1H-benzo[c]azepinium; iodide → 3-methyl-1,2,3,4,5,6-hexahydro-1H-3-benzazocine (188570-17-4) + 2,2-dimethyl-2,3,4,5-tetrahydro-1H-2-benzazepinium iodide + 2-Methyl-11-methylene-2-aza-spiro[5.5]undeca-7,9-diene + 2-methyl-1,2,3,4-tetrahydro-1H-2-benzazepine (188570-15-2)

Guidance literature:

With 4 A molecular sieve; cesium fluoride; In N,N-dimethyl-formamide; for 24h; Yields of byproduct given; Ambient temperature;

DOI:10.1021/jo962226j

Reference yield: 84.0%

benzophenone (119-61-9) + 2-methyl-1,2,3,4-tetrahydro-1H-2-benzazepine (188570-15-2) → 1-(α,α-diphenylmethylcarbinol)-2-methyl-2,3,4,5-tetrahydro-1H-2-benzazepine

Guidance literature:

2-methyl-1,2,3,4-tetrahydro-1H-2-benzazepine; With boron trifluoride diethyl etherate; In tetrahydrofuran; at 0 ℃; for 0.5h;

With sec.-butyllithium; In tetrahydrofuran; pentane; at -78 ℃; for 1h;

benzophenone; In tetrahydrofuran; pentane; at -78 - -40 ℃; for 1h;

DOI:10.1016/j.tetlet.2005.07.110

Reference yield: 31.0%

benzophenone (119-61-9) + 2-methyl-1,2,3,4-tetrahydro-1H-2-benzazepine (188570-15-2) → 5-(α,α-diphenylmethylcarbinol)-2-methyl-1,2,3,4-tetrahydro-1H-2-benzazepine

Guidance literature:

2-methyl-1,2,3,4-tetrahydro-1H-2-benzazepine; With sec.-butyllithium; In diethyl ether; toluene; pentane; at -78 - 0 ℃;

benzophenone; In diethyl ether; toluene; pentane; at -78 - -30 ℃;

DOI:10.1016/j.tetlet.2005.07.110

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